Gymnemagenin NEW
| Price | $98 | $328 | $493 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Gymnemagenin | CAS No.: 22467-07-8 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Gymnemagenin |
| Description | Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity. |
| Animal Research | Diabetes was induced in overnight-fasted rats by intravenous injection of 200 mg/kg body weight streptozotocin using a 5% solution of freshly prepared streptozotocin in 0.1 M citrate buffer (pH 4.5). Rats in the normal group were injected with a 0.1 M citrate buffer (pH 4.5) solution alone. A total of 40 rats (20 STZ-treated diabetic rats, 20 normal rats) were fed a basal diet for 4 weeks. The rats were divided into four groups (10 rats/group): group 1 (control), rats were fed the basal diet alone; group 2 (G. sylvestre-fed), rats were fed the basal diet plus Gymnemagenin (100 mg/kg/bw/day); group 3 (STZ-treated), STZtreated rats were fed the basal diet alone; group 4 (STZ-treated?G. sylvestre-fed), STZ-treated rats were fed the basal diet plus Gymnemagenin (100 mg/kg/bw/day). |
| In vivo | Gymnemagenin exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. Gymnemagenin decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. Gymnemagenin to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (59.2 mM) |
| Keywords | Inhibitor | Gymnema,sylvestre | Gymnemagenin | inhibit |
| Inhibitors Related | SR9243 | GW6340 | T0901317 | GSK3987 | SR9238 | GSK2033 | BE1218 | (20S)-Protopanaxatriol | GW3965 hydrochloride | Rovazolac |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Anti-Viral Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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