Product Details
| Product Name:
GW604714X |
CAS No.:
853953-65-8 |
| Purity:
98.05% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | GW604714X |
| Description | GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate |
| In vitro | Direct measurement of pyruvate transport into rat liver and yeast mitochondria confirmed that these agents inhibited the mitochondrial pyruvate carrier (MPC) with K(i) values <0.1 μM. Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites (pmol per mg protein) and their K(i) (nM) of 56.0 and 0.057 nM for the more hydrophobic GW604714X. GW604714X inhibited l-lactate transport by the plasma membrane monocarboxylate transporter MCT1, but at concentrations more than four orders of magnitude greater than the MPC. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMF : 5 mg/mL (10.61 mM), Sonication is recommended.
DMSO : 4 mg/mL (8.48 mM)
|
| Keywords | Inhibitor | mitochondrial respiration | Mitochondrial Metabolism | GW604714X | Parkinson's Disease | MCT1 | pyruvate | Alzheimer's Disease | GW-604714X | inhibit | MPC |
| Inhibitors Related | Imeglimin hydrochloride | Rotenone | Glibenclamide | Tricarballylic acid | Thiabendazole | Boscalid | α-Lipoic Acid | (-)-Epigallocatechin Gallate | Lipoic acid | Daidzin | D-Histidine | Nerol |
| Related Compound Libraries | Cuproptosis Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | NO PAINS Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States