Product Details
| Product Name:
Guselkumab |
CAS No.:
1350289-85-8 |
| Purity:
98.97% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | Guselkumab |
| 描述 | Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit. Guselkumab binds to human cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab can inhibit the production of cytokines downstream of IL-23 signaling pathway, and can be used in the study of psoriatic arthritis. |
| 體外活性 | Guselkumab effectively suppresses the production of Th17 cytokines, including IL17A, IL-17F, and IL-22, in mouse splenocytes stimulated with IL-23 concentrations of 0.5 or 1 ng/mL, demonstrating IC50 values between 0.016-0.080 nM. It also inhibits the IL-23 (10 or 100 ng/mL) driven production of IL-10 in human NKL cells. However, guselkumab does not impact the IL-12 (0.1 ng/mL) mediated production of interferon γ (IFNγ) in NK92MI cells. In combination with IBI112, guselkumab can prevent IL-23-induced STAT3 phosphorylation, showing an IC50 of 102.1100±2.0053 nM. Additionally, guselkumab blocks the induction of mIL-17 production by hIL-23 in a dose-dependent manner with an IC50 of 4.9743 ±1.2847 nM and inhibits IL-17F production in cynomolgus monkeys with an IC50 of 16.7950 nM. |
| 存儲(chǔ)條件 | store at low temperature | store at -80°C | Shipping with blue ice. |
| 關(guān)鍵字 | Guselkumab | CNTO-1959 | CNTO1959 |
| 相關(guān)產(chǎn)品 | Inosine pranobex | Apilimod mesylate | Amlexanox | Dexamethasone acetate | Bornyl acetate | L-Arginine | Bergenin | Dexamethasone | α-Terpineol | Diallyl disulfide | Linalool | Apilimod |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States