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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>GSK215
GSK215
  • GSK215

GSK215 NEW

Price $127 $317 $497
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: GSK215 CAS No.: 2743427-26-9
Purity: 99.3% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱GSK215
描述GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation.
體外活性GSK215 induced degradation is proteasome and ubiquitin dependent. GSK215 (0.1-1000 nM; 2 h) effectively increases the FAK degradation by >90% and determines a DC50 of 1.3 nM in A549 cells[1]. GSK215 (100 nM, 48 h) inhibits migration, invasion and collagen deposition in A549 cells. GSK215 (above 100 nM, 6h) reduces primarily kinases CDK7, RPS6KA3, MET and GAK[1].
體內(nèi)活性GSK215 (8 mg/kg; i.h.; once) degrades FAK, and exhibits the Cmax and tmax values of 526 ng/mL and 0.33 hours, respectively[1].
存儲條件Shipping with blue ice.
溶解度DMSO : 225.0 mg/mL (228.4 mM ), Sonication is recommended.
關鍵字GSK215 | GSK 215 | GSK-215
相關產(chǎn)品Chloropyramine hydrochloride | ARV-471 | dBET6 | Roslin 2 bromide | Ifebemtinib FA | Ifebemtinib | Y15 | Defactinib | Masitinib | C004019
相關庫經(jīng)典已知活性庫 | 酪氨酸激酶分子庫 | 激酶抑制劑庫 | 已知活性化合物庫 | 細胞骨架化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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