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Postion:Product Catalog >GSK046
GSK046
  • GSK046

GSK046 NEW

Price $115 $247 $397
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: GSK046 CAS No.: 2474876-09-8
Purity: 99.97% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

NameGSK046
DescriptionGSK046 (iBET-BD2) is a potent, selective, and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50 values of 264 nM [BRD2 BD2], 98 nM [BRD3 BD2], 49 nM [BRD4 BD2], and 214 nM [BRDT BD2], respectively. It exhibits immunomodulatory activity.
In vivoGSK046 (40 mg/kg/QD;?s.c. for 14 days) has immunomodulatory activity.?GSK046 exhibits Cmax (C57BL6 1589, C57B16 2993 ng/mL) and terminal elimination half-lives (C57BL6 1.8, C57B16 1.9 h) following oral administration (C57BL6 10, C57B16 40 mg/kg).?GSK046 exhibits Cmax (mouse 1589, rat 202 ng/mL) and terminal elimination half-lives (mouse 1.8, rat 1.4 h) following oral administration (mouse 10, rat 10 mg/kg)[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 83.33 mg/mL (201.05 mM), Sonication is recommended.
KeywordsGSK-046 | Epigenetic Reader Domain | BRDT | BRD2 | inhibit | GSK046 | immuno-inflammation | BRD4 | GSK 046 | Inhibitor | BD2 | BRD3
Inhibitors RelatedABBV-744 | CeMMEC1 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | J-147 | Anacardic Acid | Curcumin | dBET6 | Piflufolastat | Naphthol AS-E | Bisdemethoxycurcumin | GSK1379725A
Related Compound Libraries細(xì)胞重編程化合物庫 | 組蛋白修飾化合物庫 | 經(jīng)典已知活性庫 | 表觀遺傳庫 | 抑制劑庫 | NO PAINS 化合物庫 | 口服活性化合物庫 | PPI抑制劑庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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