Product Details
| Product Name:
GS-9256 |
CAS No.:
1001094-46-7 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | GS-9256 |
| Description | GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1]. |
| In vitro | GS-9256 demonstrates potent antiviral activity with a mean EC50 of 20 nM across a concentration range of 0.002-0.183 μM in GT1b huh-luc cells harboring a luciferase-encoding replicon [1]. Furthermore, at 3 μM, GS-9256 maintains efficacy against all tested resistant mutations in NS5B and NS5A inhibitors, showcasing its metabolic stability in microsomes and hepatocytes from rodents, dogs, and humans [1]. |
| In vivo | GS-9256 exhibits high bioavailability in mice (approximately 100%) when administered intravenously at 1 mg/kg with a 30-minute exposure, while showing moderate bioavailability in rats (14%), dogs (21%), and monkeys (14%). The compound's elimination half-life spans approximately 2 hours in mice, 0.6 hours in rats, 5 hours in dogs, and 4 hours in monkeys. Regarding the pharmacokinetic parameters at indicated doses for each species (IV: 2 mg/kg in mice, 1 mg/kg in rats, dogs, and monkeys; Oral: 50 mg/kg in mice, 5 mg/kg in rats and monkeys, and 4 mg/kg in dogs), they are as follows: for the CD-1 mouse, Sprague-Dawley rat, Beagle dog, and Cynomolgus monkey, the clearance (CL) is 2.0, 1.26, 0.04, and 0.33 L/h/kg respectively, while the volume of distribution at steady state (Vss) is 2.3, 0.16, 0.09, and 0.27 L/kg respectively [1]. |
| Storage | Shipping with blue ice. |
| Keywords | GS 9256 | GS9256 | GS-9256 | KX-1141 | KX 1141. |
| Inhibitors Related | EIDD-1931 | RO8191 | Ribavirin | Sofosbuvir | Deferiprone | Ombitasvir | Artemisinin | HCV-IN-29 | Honokiol | Resiquimod |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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