Griseofulvin NEW
| Price | $40 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Griseofulvin | CAS No.: 126-07-8 |
| Purity: 95.83% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Griseofulvin |
| Description | Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections. |
| Cell Research | The cells (5× 103/mL) are incubated in triplicate in a 96-well plate in the presence or absence of indicated concentration of Griseofulvin in a final volume of 0.2 mL for different time intervals at 37 ℃. Thereafter, 20 μL MTT solution (5 mg/mL in PBS) is added to each well. After a 2-hour incubation at 37 ℃, 0.1 mL lysis buffer (20% SDS, 50% dimethylformamide) is added, incubation is continued overnight at 37 ℃, and then the optical density at 570 nm is measured by plate reader. (Only for Reference) |
| In vitro | Griseofulvin exhibits effective anti-infective activity in vivo. When administered in conjunction with nocodazole (5 mg/kg), Griseofulvin significantly enhances the efficacy of nocodazole, resulting in the cessation of tumor growth. |
| In vivo | In vitro tests have demonstrated that the minimum inhibitory concentration (MIC) of Griseofulvin against various dermatophytes ranges between 0.14 to 0.6 μg/mL. Griseofulvin's primary mechanism of action on cellular mitosis is the disassembly of spindle microtubules. Additionally, Griseofulvin has the capacity to induce chromosomal structural abnormalities in mammalian cells. It is effective in combating different types of skin fungi, including species from the genera Microsporum, Trichophyton, and Epidermophyton. However, it is not sensitive to other fungi, such as Scopulariopsis and Hendersonula, and has almost no effect on yeasts. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (170.08 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Apoptosis | Antibiotic | Fungal | Inhibitor | inhibit | Griseofulvin |
| Inhibitors Related | Neomycin sulfate | Stavudine | Dehydroacetic acid sodium | Ampicillin sodium | Kanamycin sulfate | Sodium 4-phenylbutyrate | Sulfamethoxazole sodium | Doxycycline | Tributyrin | Geraniol | Salicylic acid | Oleic acid |
| Related Compound Libraries | Pediatric Drug Library | Drug-induced Liver Injury (DILI) Compound Library | Anti-Cancer Clinical Compound Library | Microtubule-Targeted Compound Library | Drug Repurposing Compound Library | Natural Product Library | Microbial Natural Product Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | RO5 Drug-like Natural Product Library | Human Metabolite Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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