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Postion:Product Catalog >API>Digestive system drugs>Emetics and antiemetics>Granisetron Hydrochloride
Granisetron Hydrochloride
  • Granisetron Hydrochloride
  • Granisetron Hydrochloride
  • Granisetron Hydrochloride
  • Granisetron Hydrochloride
  • Granisetron Hydrochloride

Granisetron Hydrochloride

Price Get Latest Price
Package 25Kg/Bag
Min. Order: 2Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-12-23

Product Details

Product Name: Granisetron Hydrochloride CAS No.: 107007-99-8
Min. Order: 2Kg/Bag Purity: 99% up, High Density
Supply Ability: 20 tons Release date: 2024/12/23

Product Information

Product name

Granisetron Hydrochloride

CAS No.

107007-99-8

Molecular Formula

C18H21D3N4O

Molecular Weight

348.87

Quality Standard

97% up by HPLC

Appearance

White powder

COA of Granisetron Hydrochloride

  Items

Specifications

Results

Appearance

White or almost white powder

White powder


Identification

IR spectrum: Simple IR spectrum comparable with that of the standard

Conforms

Chloride: Positive

Conforms

Solubility

Freely soluble in water,sparingly soluble in methanol very slightly soluble in methylene chloride.

Conforms

Appearance of solution

Clear and colourless

Conforms

pH

4.0-6.5

5.88

Impurity E(by TLC)

NMT 0.5%

< 0.5%

Loss on drying

NMT 0.5%

0.05%

Sulphated ash

NMT 0.1%

0.02%





Related substances

 2-methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]non-3- yl]-2H-indazole-3 carboxamide (Impurity A): NMT 1.0%

ND

N-[(1R,3r,5S)-9-methyI-9-azabicyclo[3.3.1]non-3-yI]-1H-in dazole-3 carboxamide (Impurity B): NMT 0.5%

ND

N-[(1R,3r,5S)-9-azabicyclo[3.3.1]non-3-yl]-1-methyl-1H-in dazole-3 carboxamide ( Impurity C):NMT 0.2%

0.01%

1-methyI- 1H-indazole-3- carboxylic acid ( Impurity D) : NMT0.1%

ND

Any other impurity: NMT 0.10%

99.26%

Total impurities: NMT 1.0%

0.01%

Residual solvents

Ethanol: NMT 1000ppm

280ppm

Isopropanol: NMT1000ppm

ND

Dichloromethane

ND

 Assay by HPLC

 97.0%-102.0% (dried basis)

100.0%

 Endotoxins

 NMT 125 EU/mg

< 125 EU/m

Microbial limits

Total aerobic microbial count: NMT 100CFU/g

Conforms

Absence of S. aureus, E.Coli, P.aeruginosa, Salmonelia apecies

Conforms

Conclusion

Meet the EP9.0 specifications

Usage

Function of Granisetron Hydrochloride


Granisetron hydrochloride is an antiemetic drug, mainly suitable for nausea and vomiting caused by radiotherapy, cytotoxic drug chemotherapy, and surgery. It has a better preventive and therapeutic effect. The mechanism of controlling nausea and vomiting is mainly through antagonism Central chemoreceptors and related receptors of neurotransmitters in the peripheral nervous system can inhibit the occurrence of nausea and vomiting. The selectivity of drug treatment is relatively high, and the adverse reactions to the central nervous system are relatively few. Less cause excessive sedation and other adverse reactions.


Granisetron hydrochloride is also used for surgical prevention. Generally, it only needs to be administered once. The preventive effect on nausea and vomiting can be more than 24 hours, so the effect time is relatively long. When using it, you need to pay attention to the gastrointestinal tract. Patients with obstruction are contraindicated.

Article illustration

Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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