Gramicidin NEW
| Price | $42 | $50 | $62 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Gramicidin | CAS No.: 1405-97-6 |
| Purity: 97.03% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Gramicidin |
| 描述 | Gramicidin (Gramicidine) is an antimicrobial peptide. Gramicidin dimers form ion channel-like pores in the cell membranes and organelles of bacterial and animal cells, allowing inorganic monovalent ions, such as potassium and sodium ions, to pass freely through the pores by diffusion, disrupting the important ionic gradient between membranes and thus killing the cells by various actions. Gramicidin is effective against Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus, but is not as effective against Gram-negative bacteria such as Escherichia coli. |
| 體外活性 | METHODS: OC cells OVCAR8, A2780 and SKOV3 were treated with Gramicidin (0.33-3 μM) for 24-72 h. Cell viability was measured by WST-1 assay. RESULTS: Gramicidin inhibited the growth of OC cells in a dose- and time-dependent manner, with IC50 values of 0.0763, 0.1856 and 0.1148 μM for OVCAR8, SKOV3 and A2780 cells, respectively, at 72 h.[1] METHODS: Human gastric cancer cells SGC-7901 were treated with Gramicidin (0.3-3 μM) for 24-48 h. Apoptosis was detected by Flow cytometry. RESULTS: Gramicidin promoted apoptosis in SGC-7901 cells in a time- and dose-dependent manner. When cells were incubated with Gramicidin for 48 h, the percentage of viable cells decreased to 54.2% with 3 μM Gramicidin treatment compared to control. [2] |
| 體內(nèi)活性 | METHODS: To study the effect on in vivo allograft survival, Gramicidin (2-4 mg/kg) was injected intraperitoneally into ectopic heart transplanted rats once daily for 6 days. RESULTS: Graft pulsation in the control group ceased at 5.4+/-0.4 days post-transplantation due to acute allograft rejection, whereas recipients in the group receiving intraperitoneal injections of Gramicidin (2-4 mg/kg) had a significant prolongation of graft pulsation to 15.4+/-4.3 or 18.4+/-3.9 days post-transplantation, respectively. [3] |
| 存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (26.56 mM) |
| 關(guān)鍵字 | Bacterial | Inhibitor | Antibiotic | inhibit | Gramicidin |
| 相關(guān)產(chǎn)品 | Dehydroacetic acid sodium | Chlorobutanol hemihydrate | Chitosan (MW 150000) | Ampicillin sodium | Doxycycline (hyclate) | Cefaclor monohydrate | Sulfamethoxazole sodium | Doxycycline | EDTA copper(II) disodium salt | Dimethyl sulfoxide | Meldrum's acid | Crystal Violet |
| 相關(guān)庫 | FDA上市及藥典收錄分子庫 | 經(jīng)典已知活性庫 | 環(huán)肽庫 | 天然產(chǎn)物庫 | 微生物天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | FDA 上市藥物庫 | 抗感染天然產(chǎn)物庫 | 已知活性化合物庫 | 臨床前化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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