Gomisin J NEW
| Price | $39 | $59 | $122 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Gomisin J | CAS No.: 66280-25-9 |
| Purity: 99.69% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Gomisin J |
| Description | Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. |
| In vitro | Gomisin J attenuated lipid accumulation in OA-induced HepG2 cells.?It also suppressed the expression of lipogenic enzymes and inflammatory mediators and increased the expression of lipolytic enzymes in OA-induced HepG2 cells.?Furthermore, the use of specific inhibitors and fetuin-A siRNA and liver kinase B1 (LKB1) siRNA transfected cells demonstrated that gomisin J regulated lipogenesis and lipolysis via inhibition of fetuin-A and activation of an AMP-activated protein kinase (AMPK)-dependent pathway in HepG2 cells[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (128.71 mM) |
| Keywords | Ca channels | Ca2+ channels | Inhibitor | AMPK | AMP-activated protein kinase | inhibit | Gomisin J | Calcium Channel |
| Inhibitors Related | Nisoldipine | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | Adenosine monophosphate | Adenosine 5'-monophosphate monohydrate | Methyl cinnamate | Ethyl cinnamate | Metformin hydrochloride | 1-Octanol | 2-Nitrobenzoic acid | Chitosan oligosaccharide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Natural Product Library | Neuroprotective Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Ion Channel Targeted Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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