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Postion:Product Catalog >GNF-PF-3777
GNF-PF-3777
  • GNF-PF-3777

GNF-PF-3777 NEW

Price $46 $124 $187
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: GNF-PF-3777 CAS No.: 77603-42-0
Purity: 97.88% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameGNF-PF-3777
DescriptionGNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2) with a Ki of 0.97 μM.
In vitroGNF-PF-3777 (Compound 5i) is a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity (EC50: 0.82 μM) [2]. GNF-PF-3777 has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogs lack LORA activity [3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 1 mg/mL, Sonication is recommended.
KeywordsGNFPF3777 | GNF-PF 3777 | GNF PF 3777 | Inhibitor | inhibit | Indoleamine 2,3-Dioxygenase (IDO) | GNF-PF3777 | GNF-PF-3777
Inhibitors RelatedPalmatine chloride | Coptisine chloride | Necrostatin-1 | IDO-IN-7 | IDO1-IN-1 | Indoximod | Palmatine | IDO inhibitor 1 | Epacadostat | β-Lapachone | IDO5L | IDO-IN-12
Related Compound LibrariesBioactive Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | NO PAINS Compound Library | Immuno-Oncology Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.
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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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