INCI： Glabridin

Glycyrrhiza glabra extract

Molecular Formula :C20H20O4

Molecular Mass : 324.376

CAS No.:59870-68-7

EINECS: 611-908-7

• PSA：58.92000

• LogP：4.00070

• Loss on drying :    1.13% 

• Residue on ignition: 0.11% 

• Heavy metals: ≤ 10ppm 

• Total number of bacteria: ≤ 100Cfu/g 

• Flavonoid test:  Positive 

Structure

Functions: 

1: Tyrosinase Inhibition

Human tyrosinase is an essential enzyme that regularly produces melanin, which changes 

the skin or eyes from brown to black. We know that exposure of the skin to UV light causes 

a number of reactions (e.g. the appearance of inflammation), and as the phospholipid membranes 

of the skin tissues are damaged by the UV-induced production of reactive oxygen species, 

this histological alteration manifests itself in the appearance of erythema and hyperpigmentation. 

Reactive oxygen species is a substance that causes skin pigmentation, so inhibiting its production 

inhibits melanin production. Light glycyrrhizin is the most expensive and effective whitening 

ingredient among all whitening ingredients, "Materia Medica China" has said that the whitening 

effect of light glycyrrhizin is 232 times that of ordinary Vitamin C, 16 times that of hydroquinone, 

and 1,164 times that of arbutin, so light glycyrrhizin is known as the "whitening gold". 

So it is called "Whitening Gold".

2: 

Anti-inflammatory effect

The anti-inflammatory activity of photoglycodine was experimentally verified by exposing 

guinea pigs to UV-induced hyperpigmentation and then applying a 0.5% solution of photoglycodine, 

which was found to reduce skin inflammation induced by UV stimulation. 

The a-value was used to indicate erythema on the skin. By recording the a-values (colourimeter readings)

 before irradiation, after irradiation, and with the use of photoglycyrrhizidine, 

it was possible to calculate the degree of inflammation reduction. 

The researchers investigated the inhibition of cyclooxygenase activity by photoglycodine. 

Cyclooxygenase is the enzyme that converts arachidonic acid into prostaglandins, 

which are inflammatory factors. Compared to a control group (using the current cyclooxygenase inhibitor, indoxacarb), photoglycyrrhizidine was able to achieve inhibition of cyclooxygenase. 

It is trustworthy that photoglycyrrhizidine affects the production of arachidonic acid by inhibiting cyclooxygenase, thus reducing inflammation.

3: Antioxidant effect

Photoglycyrrhiza glabra has a strong scavenging effect of free radicals. Vitamin C, vitamin E and 

beta-carotene are recognised as the three kings of antioxidant and anti-aging. 

Photoglycyrrhiza glabra has an anti-aging ability comparable to that of vitamin E and is a 

natural antioxidant, and it has been reported that its antioxidant effect is significantly superior to 

that of BHA and BHT, among others.  It has been reported in the literature that liquorice can be 

used to reduce corticosteroids in infectious skin diseases and can enhance the effects of steroids.

4: Cosmetic Applications

Glycyrrhizin has excellent anti-inflammatory, antioxidant and antimelanogenic properties, which have led to its use as an ingredient in various cosmetic and medical treatments (e.g., creams, lotions, shower gels, etc.). It can be made into whitening creams and patented products of this type are already on the market.

Dosage: In cosmetics, in order to achieve the whitening effect, the patented recommended dosage is 0.001-3% of glycyrrhizin, preferably 0.001-1%. Add 1:10 with glycerin, at low temperature. Topical Photoglycoside inhibits melanin formation, it has excellent tyrosinase inhibiting activity, prevents tanning, line spots and sun spots, the recommended dosage is 0.0007-0.05%. Studies have shown that as little as 0.05% of glycyrrhizin, 0.3% of aloe vera powder, 1% of niacinamide, and 1% of AA2G paired with each other can inhibit melanin ligase by as much as 98.97%, and for testosterone suppression and acne treatment, glycyrrhizin should be used at a dosage of 0.01-0.5%.