Glaucocalyxin B NEW
| Price | $166 | $365 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Glaucocalyxin B | CAS No.: 80508-81-2 |
| Purity: 99.13% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Glaucocalyxin B |
| Description | Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM). |
| Cell Research | The microglia cell viability is assessed by MTT assay. Cells are seeded in 96-well plates at the density of 5 × 10^4 cells/well. The cell culture supernatant is discarded after treatment with various agents, and then 30 μL of MTT (0.5 mg/mL) solution is added into each well. After incubation for 4 h at 37 °C, 100 μL of DMSO is added into each well to dissolve the formazan dye, and then the absorbance of solubilized formazan is measured by microplate reader [3]. |
| In vitro | Glaucocalyxin A (GlnA) and B (GlnB) dose-dependently reduce HL-60 cell growth (IC50s: 6.15 and 5.86 μM at 24 h) and induce apoptosis, G2/M-phase cycle arrest, DNA damage, and the accumulation of reactive oxygen species (ROS) in these cells[1]. GlnB also inhibits the proliferation of human cervical cancer cells in vitro by inducing apoptosis and autophagy, potentially mediated through the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway, and dose-dependently reduces the proliferation of HeLa and SiHa cervical cancer cell lines, increases the apoptotic cell population, and enhances poly (ADP ribose) polymerase 1 cleavage[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : Soluble |
| Keywords | Inhibitor | inhibit | Glaucocalyxin B | Autophagy |
| Inhibitors Related | Hydroxychloroquine | Guanidine hydrochloride |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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