GKT136901 hydrochloride NEW
| Price | $39 | $73 |
| Package | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: GKT136901 hydrochloride | CAS No.: 1254507-01-1 |
| Supply Ability: 10g | Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | GKT136901 hydrochloride |
| 描述 | GKT136901 hydrochloride is a NOX-1/4 inhibitor, a selective scavenger of peroxynitrite, which inhibits METH-induced ROS production. |
| 體外活性 | GKT136901 hydrochloride is a potent, selective and orally active NADPH oxidase (NOX1/4) inhibitor with Ki values of 160 nM and 165 nM, respectively. [1] GKT136901 hydrochloride significantly reduced the production of superoxide radical anion and H2O2 in MPT cells induced by high D-glucose and eliminated the effect of high D-glucose on p38MAP kinase activation in MPT cells after treatment with GKT136901 hydrochloride at a dose of 10 μM for 30 min. [3] GKT136901 hydrochloride attenuated methamphetamine (METH)-induced oxidative stress in HBMEC treated at a dose of 10 μM for 2 hours and effectively protected HBMEC from METH-induced blood-brain barrier (BBB) dysfunction. [5] |
| 體內(nèi)活性 | GKT136901 hydrochloride exhibited nephroprotective effects in a mouse model of type 2 diabetes mellitus when administered orally at a dose of 30-90 mg/kg daily for 16 weeks. [6] |
| 存儲條件 | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 2 mg/mL (4.96 mM), Sonication is recommended. DMSO : 50 mg/mL (123.99 mM), Sonication is recommended. |
| 關(guān)鍵字 | GKT 136901 Hydrochloride |
| 相關(guān)產(chǎn)品 | GLX351322 | APX-115 free base | NoxA1ds acetate(1435893-78-9 free base) | Ketoconazole | Aucuparin | Protosappanin A | Phox-I2 | ML-090 | APX-115 | GKT136901 | Setanaxib | VAS 3947 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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