GFB-8438 NEW
| Price | $48 | $74 | $119 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: GFB-8438 | CAS No.: 2304549-73-1 |
| Purity: 99.58% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | GFB-8438 |
| Description | GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). |
| Animal Research | Sprague Dawley rats (DOCA-salt rat model of FSGS);30 mg/kg; Administration:s.c.; daily for 3 weeks |
| In vitro | GFB-8438 is a novel TRPC5 inhibitor. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro. |
| In vivo | GFB-8438is also efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of FSGS, significantly reducing both total protein and albumin concentrations in urine |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 27.5 mg/mL (71.1 mM) |
| Keywords | mouse | selective | Transient receptor potential channels | GFB-8438 | Inhibitor | inhibit | remodeling | TRP Channel | deoxycorticosterone | loss | subtype | cytoskeletal | GFB 8438 | synaptopodin | podocytes | GFB8438 | kidney | disease | acetate |
| Inhibitors Related | (+)-Camphor | AP 18 | Methyl syringate | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Methyl salicylate | SKF-96365 hydrochloride |
| Related Compound Libraries | 經(jīng)典已知活性庫 | 疼痛相關化合物庫 | 神經(jīng)信號分子庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1240.00/10mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $48.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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