Gefitinib hydrochloride NEW
| Price | $33 | $47 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Gefitinib hydrochloride | CAS No.: 184475-55-6 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Gefitinib hydrochloride |
| Description | Gefitinib hydrochloride (ZD-1839 hydrochloride) is an orally active selective and potent tyrosine kinase (EGFR) inhibitor. Gefitinib hydrochloride exhibits antitumor activity, selectively inhibits EGF-stimulated tumor cell growth, induces cellular autophagy, improves lung dysfunction, and inhibits inflammation. Gefitinib hydrochloride has antitumor activity, selectively inhibits EGF-stimulated tumor cell growth, induces cellular autophagy, ameliorates lung dysfunction, and inhibits the progression of inflammation and fibrosis. |
| In vitro | Gefitinib hydrochloride (0.01-0.1 mM) increased phosphotyrosine loading of the receptor by inducing EGFRvIII dimerization, enhanced ERK signaling, and stimulated cell proliferation and anchorage-independent growth, especially upon prolonged exposure of EGFRvIII-expressing cells. In contrast, Gefitinib hydrochloride (1-2 mM) significantly reduced phosphotyrosine loading of EGFRvIII and inhibited EGFRvIII-mediated proliferation and anchorage-independent growth. [1] Gefitinib hydrochloride inhibited monolayer growth of non-transformed cells driven by EGF with an IC50 of 20 nM. [2] Gefitinib hydrochloride also inhibited the proliferation of CALU-3 and GLC82 cells with an IC50 of 2 μM. [3] |
| In vivo | Gefitinib hydrochloride (150 mg/kg, orally) in combination with metformin significantly inhibited the growth of tumor xenografts formed by subcutaneous transplantation of H1299 or CALU-3 GEF-R cells in nude mice. [3] In rats treated with radiation therapy, Gefitinib hydrochloride exacerbated the inflammatory response in the lungs, including the infiltration of inflammatory cells and the increase of pro-inflammatory factors, whereas Gefitinib hydrochloride served to slow down the fibrotic remodeling of the lungs by inhibiting the proliferation of lung fibroblasts. [4] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : < 0.1 mg/mL (insoluble) H2O : 4 mg/mL (8.28 mM), Sonication is recommended. |
| Inhibitors Related | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Afatinib Dimaleate | Erlotinib hydrochloride | Erlotinib | Neratinib | Chalcone | Osimertinib mesylate | Genistein | Khellin | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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