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Postion:Product Catalog >GDC-0339
GDC-0339
  • GDC-0339

GDC-0339 NEW

Price $1650 $2150 $3730
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: GDC-0339 CAS No.: 1428569-85-0
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameGDC-0339
DescriptionGDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of the pan-Pim kinase (Kis: 0.03 nM, 0.1 nM, and 0.02 nM for Pim1, Pim2, and Pim3, respectively).
In vitroGDC-0339 is cytostatic (IC50 of 0.1 μM for MM.1S cells). GDC-0339 treatment shows a constellation of Pim downstream signaling events. Which is consistent with inhibition of Pim kinases[2].
In vivoGDC-0339 has a half-life of t1/2=0.9 h. GDC-0339 (1-300 mg/kg; p.o; daily; for 21 days) is potently in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models [2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 50 mg/mL (107.41 mM)
KeywordsPim | Pim kinases | inhibit | GDC 0339 | GDC0339 | GDC-0339 | Inhibitor
Inhibitors RelatedXL413 hydrochloride | SGI-1776 | CK2/ERK8-IN-1 | M-110 | (Z)-SMI-4a | XL413 HCl | CX-6258 hydrochloride | Pim-1 kinase inhibitor 4 | Pim-1/2 kinase inhibitor 1 | Pim-1 kinase inhibitor 8 | TP-3654 | K00135

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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