Gabapentin cas 60142-96-3

Use of Gabapentin

Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.IC50 Value: 140 nM (α2δ subunit of calcium channel) [1]Target: Calcium Channelin vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release [2]. A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM) [3].in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody [4].Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified [5]

Company Introduction

Hebei Best Biological Technology Co., Ltd. is a modern advanced enterprise specializing in production and exportation of APIs,Pharmaceutical intermediates, peptides, plant extracts etc. Our products are widely used in medicine, health care products,cosmetics, nutritional supplements and food additives areas.

Why Choose Us

1. Rich experience

We specialize in this filed for many years, our steriods and hormones exported to all over the world and established long friendly relations of cooperation with them.

2. Great quality,purity and favorable

Good quality is one of our biggest secret to success; you can get the best quality and service from us.

3. Safest and fastest delivery

We have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment. Fast and discreet shipment will be arranged to pass customs.

4. Good package

Unique ways to ship 10g to 100kg powders to your destination. We offer melting powder into liquid service and ship the liquid in special bottles.

5. Great after-sales service

Any needs or questions contact me freely.

FAQ

Q1: What is your MOQ?

A:Our MOQ is 10g, 100g and 1kg for your evaluation quality of our goods on the condition that sample charge is 100% paid.

Q2: Is there any discount?

A:Yes, for larger quantity, we always support with better price.

Q3: What payment terms do you accept ?

A:We'd like to accept T/T, L/C, Paypal, or Western Union.

Q4: How long will it take to get the goods?

A:Depending on your location, For small order, please expect 5-7 days by DHL, UPS, TNT, FEDEX, EMS. For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q5: How do you treat quality complaint?

A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6: How can we trust you?

A: You are always warmly welcomed to visit us at any time. Before we start B2B, MIC has audited our company on-spot and approved our credit.

Q7: Do you test all your goods before delivery?

A: Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.

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