GABAA receptor agent 7 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: GABAA receptor agent 7 | CAS No.: 2376841-18-6 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | GABAA receptor agent 7 |
| Description | GABAA receptor agent 7 (compound 5c) is a potent positive modulator of the GABAA receptor with anticonvulsant activity in vitro and in vivo, and low neurotoxicity, making it suitable for epilepsy research [1]. |
| In vitro | GABAA receptor agent 7 (compound 5c) exhibits anticonvulsant properties, demonstrating an inhibitory concentration (IC50) of 0.452 μM in the 4-AP induced hyper-excitability model [1]. Additionally, it enhances GABA-induced activation of the GABAA1 receptor dose-dependently within a concentration range of 0.01-100 μM over a period of 0-140 seconds, with an effective concentration (EC50) of 3.08 μM [1]. |
| In vivo | GABAA receptor agent 7 demonstrates anticonvulsant properties in mice, achieving an effective dose 50 (ED50) of 31.81 mg/kg and a toxic dose 50 (TD50) of 547.89 mg/kg [1]. This compound specifically mitigates seizures induced by pentylenetetrazol (PTZ) without affecting those caused by maximal electroshock (MES) in mice [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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