Product Details
Product Name:
FzM1 |
CAS No.:
1680196-54-6 |
Purity:
99.89% |
Supply Ability:
10g |
Release date:
2024/11/11 |
Product Introduction
Bioactivity
名稱 | FzM1 |
描述 | FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway. |
體外活性 | FzM1 inhibited Gli activity less efficiently than TCF/LEF activity (log EC50 of ?4.6 and ?5.7, respectively). On the contrary, it did not modulate CRE activity (log EC50 > ?4.0), indicating that it does not influence GPCRs linked to G proteins[2]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 65 mg/mL (180.34 mM), Sonication is recommended.
|
關(guān)鍵字 | FzM1 |
相關(guān)產(chǎn)品 | Urea | PRI-724 | Wnt pathway activator 1 | L-quebrachitol | MSAB | EMT inhibitor-1 | Wogonin | CHIR-99021 | XAV-939 | Nefopam hydrochloride | KY-05009 | Bisdemethoxycurcumin |
相關(guān)庫 | 經(jīng)典已知活性庫 | 抗卵巢癌化合物庫 | 抗癌細(xì)胞代謝庫 | 神經(jīng)保護(hù)化合物庫 | 干細(xì)胞分化化合物庫 | 已知活性化合物庫 | 細(xì)胞骨架化合物庫 | 神經(jīng)元分化化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |