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Postion:Product Catalog >FzM1
FzM1
  • FzM1

FzM1 NEW

Price $35 $58 $100
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: FzM1 CAS No.: 1680196-54-6
Purity: 99.89% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱FzM1
描述FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
體外活性FzM1 inhibited Gli activity less efficiently than TCF/LEF activity (log EC50 of ?4.6 and ?5.7, respectively). On the contrary, it did not modulate CRE activity (log EC50 > ?4.0), indicating that it does not influence GPCRs linked to G proteins[2].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 65 mg/mL (180.34 mM), Sonication is recommended.
關(guān)鍵字FzM1
相關(guān)產(chǎn)品Urea | PRI-724 | Wnt pathway activator 1 | L-quebrachitol | MSAB | EMT inhibitor-1 | Wogonin | CHIR-99021 | XAV-939 | Nefopam hydrochloride | KY-05009 | Bisdemethoxycurcumin
相關(guān)庫經(jīng)典已知活性庫 | 抗卵巢癌化合物庫 | 抗癌細(xì)胞代謝庫 | 神經(jīng)保護(hù)化合物庫 | 干細(xì)胞分化化合物庫 | 已知活性化合物庫 | 細(xì)胞骨架化合物庫 | 神經(jīng)元分化化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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