Product Details
| Product Name:
Fuzapladib |
CAS No.:
141283-87-6 |
| Purity:
99.65% |
Supply Ability:
10g |
| Release date:
2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Fuzapladib |
| 描述 | Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammatory cell surface to prevent inflammatory cells from adhering to vascular endothelial cells and infiltrating tissue and to control exacerbation of pancreatitis. |
| 體外活性 | Treatment with Fuzapladib(IS-741) 1μM for 3 h significantly inhibited the adhesion of HL-60 cells to HUVEC stimulated by lipopolysaccharide [1]. |
| 體內(nèi)活性 | Oral administration of Fuzapladib(IS-741) 50mg/kg significantly decreased the activity of myeloperoxidase (MPO) and the level of IL-8 in the ileum of rats for 7 consecutive days, and reduced the infiltration of inflammatory lesion multinucleate cells and Mac-1 positive cells, and effectively alleviated the ileitis induced by tritrobenzosulfonate (TNBS)[2]. |
| 存儲條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 3.79 mg/mL (10 mM)
|
| 關鍵字 | IS 741 | IS741 | Fuzapladib |
| 相關產(chǎn)品 | Neomycin sulfate | 1-Naphthaleneacetic acid potassium salt | trans-Benzylideneacetone | Benzylideneacetone | Tris(2,4-di-tert-butylphenyl)phosphate | (E/Z)-Polydatin | Indomethacin | Fluticasone (propionate) | 1-Naphthaleneacetic acid | Darapladib | Lansoprazole | Amentoflavone |
| 相關庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1kg |
|
Hpets Biotech Company (Chongqing) Co.,ltd
|
2023-03-21 |
United States