Fumitremorgin C NEW
| Price | $1360 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-21 |
Product Details
| Product Name: Fumitremorgin C | CAS No.: 118974-02-0 |
| Supply Ability: 10g | Release date: 2024/11/21 |
Product Introduction
Bioactivity
| Name | Fumitremorgin C |
| Description | Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP. |
| In vitro | Multidrug resistance (MDR) presents a significant challenge in cancer chemotherapy, but Fumitremorgin C has shown remarkable efficacy in counteracting this problem by increasing drug accumulation in multidrug-selected cell lines. Specifically, it enhances the effectiveness of doxorubicin, mitoxantrone, and topotecan by reversing mitoxantrone resistance up to 114-fold and doxorubicin resistance 3-fold in MCF-7/mtxR cells. Additionally, in S1M1-3.2 cells, Fumitremorgin C substantially boosts the toxicity of these drugs, demonstrating a 26-fold increase for doxorubicin, 93-fold for mitoxantrone, and 24-fold for topotecan. However, it does not mitigate drug resistance in cells with high levels of Pgp or MRP expression [1]. Notably, Fumitremorgin C virtually eliminates resistance mediated by BCRP in vitro, making it a valuable pharmacological tool for investigating the expression and molecular functionality of this transporter. Furthermore, it significantly raises the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells by 2.5–5.6 fold and reduces the IC50 of topotecan in BCRP-overexpressing cells to levels even lower than those in untreated vector-transfected cells [2]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (131.77 mM), Sonication is recommended. |
| Keywords | Breast cancer resistance protein | ABCG2 | 12a-Fumitremorgin C | Fumitremorgin C | Antibiotic | Inhibitor | inhibit | Bacterial | 12alpha-Fumitremorgin C | BCRP |
| Inhibitors Related | Neomycin sulfate | Dimethyl sulfoxide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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