FOXO1-IN-3 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: FOXO1-IN-3 | CAS No.: 2451093-95-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | FOXO1-IN-3 |
| Description | FOXO1-IN-3 is a highly-selective, orally active inhibitor of FOXO1 that reduces hepatic glucose production and improves insulin sensitivity and glucose regulation in db/db mice, without causing weight gain [1]. |
| In vitro | FOXO1-IN-3 (Compound 10) at 10 μM inhibits cAMP/Dexamethasone-induced mRNA expression of G6pc and Pck1 in primary hepatocytes from normal mice after 6 hours of treatment [1]. |
| In vivo | FOXO1-IN-3 (Compound 10) (16 mg/kg, oral administration, twice daily for 10 days) effectively reduced blood glucose levels in db/db mice [1]. Additionally, it showed synergistic glucose-lowering effects in Streptozotocin-induced diabetic mice with depleted β-cells when combined with FGF21 (0.45 mg/kg) [1]. FOXO1-IN-3 exhibited significant plasma exposure and oral bioavailability in mice at 1 mg/kg intravenously and 10 mg/kg orally, despite a short half-life [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $54.00/1mL |
VIP3Y
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TargetMol Chemicals Inc.
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2024-10-23 | |
| $58.00/5mg |
VIP5Y
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TargetMol Chemicals Inc.
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2024-11-11 | |
| $0.00/1g |
VIP1Y
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Wuhan Circle Star Chem-medical Technology Co.,Ltd
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2025-01-17 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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