Description of Folinic Acid from Watson Biotechnology Co., Ltd

Specifications(COA) of Folinic Acid CAS 58-05-9

Folinic acid, also known as leucovorin, is a form of folate (vitamin B9) that is used in various medical applications. It is not the same as folic acid but rather a metabolically active derivative. The main applications of folinic acid include:

### 1. **Chemotherapy Support (Methotrexate Rescue)**

   - **Methotrexate Toxicity Rescue:** Methotrexate is a chemotherapy drug that can be toxic to healthy cells as it inhibits folate metabolism. Folinic acid helps "rescue" normal cells by providing them with a form of folate they can use, thereby reducing methotrexate's toxic side effects.

   - **Enhancing Chemotherapy (5-Fluorouracil):** Folinic acid is often used alongside the chemotherapy drug 5-fluorouracil (5-FU). It enhances the effectiveness of 5-FU by stabilizing the bond between the drug and the target enzyme (thymidylate synthase), thereby improving its cancer-fighting ability.

### 2. **Megaloblastic Anemia**

   - Folinic acid is used to treat megaloblastic anemia when it results from folate deficiency, especially in people who have trouble converting folic acid to its active form, such as those with genetic defects (e.g., MTHFR mutation).

### 3. **Overdose of Folic Acid Antagonists**

   - Folinic acid is used to treat overdoses of folic acid antagonists like pyrimethamine and trimethoprim, which are found in certain medications (e.g., antibiotics and antiparasitics).

### 4. **Neurological Disorders**

   - It is used in some cases to manage or improve neurological function in conditions like cerebral folate deficiency or neurodegenerative diseases. Some research also suggests it may be beneficial in conditions such as autism spectrum disorders, though more studies are needed.

### 5. **Pernicious Anemia**

   - Though vitamin B12 is typically used to treat pernicious anemia, folinic acid may be used in combination in certain cases where there's a combined folate deficiency.

These are the main medical applications of folinic acid, especially in managing the toxic effects of certain drugs and supporting folate metabolism in specific conditions.

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