Fluoxetine
| Price | $30 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | 20tons |
| Update Time: | 2023-08-16 |
Product Details
| Product Name: Fluoxetine | CAS No.: 54910-89-3 |
| EC-No.: 611-209-7 | Min. Order: 1KG |
| Purity: >99% | Supply Ability: 20tons |
| Release date: 2023/08/16 |
Product Details
| Fluoxetine Basic information |
| Product Name: | Fluoxetine |
| Synonyms: | (+/-)-n-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine;METHYL-[3-PHENYL-3-(4-TRIFLUOROMETHYLPHENOXY)PROPYL]AMINE;AURORA KA-7692;FLUOXETINE;(+-)-benzenepropanamin;(+)or(-)-n-methyl-3-phenyl-3-(alpha,alpha,alpha-trifluoro-p-tolyl)oxy)prop;(+)or(-)-n-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine;dl-3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine |
| CAS: | 54910-89-3 |
| MF: | C17H18F3NO |
| MW: | 309.33 |
| EINECS: | 611-209-7 |
| Fluoxetine Chemical Properties |
| Melting point | 158 °C |
| Boiling point | 395.1±42.0 °C(Predicted) |
| density | 1.159±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 10.05±0.10(Predicted) |
| Fluoxetine Usage And Synthesis |
| Chemical propertis | Fluoxetine Hydrochloride: White or white crystalline solids with a melting point of 158.4 to 158.9oC. Soluble in methanol or ethanol, dissolved in acetonitrile, acetone, or chloroform, and slightly soluble in ethyl acetate, dichloromethane, or water(with sonication at pHl.2,4.5,7.0).Almost insoluble in cyclohexane, hexane or toluene. Solubility(mg/m1):Methanol and ethanol > 100, Acetone, acetonitrile and chloroform 33~100, dichloromethane 5~10, water 1~2, ethyl acetate 2 ~ 2.5, Cyclohexane, hexane and toluene 0.5 ~ 0.67. The maximum solubility in water: 14mg/ml. UV maximum absorption (methanol):227,264,268,275nm (E1cm1%372.0,29.2,29.3,21.5). Acute toxic of LD50 for large rate and small rat (mg/kg): 248, 452 oral administrations. |
| Antidepressant | Fluoxetine is an antidepressant of the selective serum reabsorption inhibitor (SSRI) type.The drug takes the form of Fluoxetine hydrochloride. Its trade name is "Prozac". The drug was developed by the Eli Lilly and Company. It has been launched into market for sale since the 1990s. This drug is used for the treatment of adult depression, obsessive-compulsive disorder, bulimia nervosa and the panic disorder that has or does not have the phobia of the square. It has good antidepressant effect and is widely used in clinical practice as a first-line antidepressant.The main pharmacological effect is to selectively inhibit the reuptake of 5 hydroxytryptamine (HT), which is released before the synapse of the central nervous system.It is also known as a selective 5- serotonin reuptake inhibitor. For other receptors, such as alpha adrenergic, beta adrenergic, 5- serotonin, and dopamine, fluoxetine had almost no binding force. Fluoxetine is well absorbed from the gastrointestinal tract after oral administration.The plasma concentration is about 6~8 hours, and eating does not affect its bioavailability. About 95% are combined with plasma proteins and are widely distributed.After taking the medicine for several weeks, the steady plasma concentration will be reached.By metabolism of the liver, the active metabolite, norfluoxetine is generated by demethylation. The half-life of fluoxetine is 4-6 days, and norfluoxetine is 4-16 days.It was mainly excreted by kidney. Because it can be secreted to breast milk, it is suggested to be cautious to pregnant women and breast-feeding women. |
| Uses | Fluoxetine in its hydrochloride salt form is marketed as numerous drugs, the most popular ofwhich is Prozac. Prozac is prescribed for depression, obsessive-compulsive disorder, bulimia,agoraphobia, and premenstrual dysphoric disorder (premenstrual syndrome). Prozac andother fluoxetine medications belong to a class of drugs called selective serotonin reuptakeinhibitors (SSRIs). When a nerve signal is sent, a neurotransmitter, such as serotonin, travelsfrom a presynaptic neuron across the synaptic gap to a postsynaptic neuron. Receptors on thepostsynaptic neuron capture the neurotransmitter, resulting in the transmission of the signal.After performing its function, the neurotransmitter is released back to the presynaptic cellin a process called reuptake. SSRIs slow down the return of serotonin to presynaptic neurons,allowing for a higher serotonin concentration on postsynaptic neurons. Because depressionand other psychological disorders are associated with low serotonin levels, Prozac and otherSSRIs help maintain serotonin levels. Prozac was thefirst SSRI antidepressant to be marketed. Because Prozac produced lesssevere side effects than other antidepressants, it became the drug of choice for treating depressionand was made available to a wider public. Its use exploded in the 1990s, with sales peakingin 2000 when revenues from Prozac reached $2.5 billion. Eli Lilly's patent on fluoxetinehydrochloride expired in August 2001; its use continued into the 21st century but on a muchsmaller scale as generic fluoxetine hydrochloride products came on the market. Since its introductionin 1986, Prozac was the most prescribed drug for antidepressant until recent yearswhen it was replaced by Zoloft, Paxil, and Lexapro as the top three antidepressants prescribedin the United States, respectively. Fluoxetine hydrochloride is most recognized as an antidepressant, but it is also used torelieve symptoms of premenstrual dysphoric disorder (PMDD) (premenstrual syndrome).Th ese symptoms include mood swings, tension, bloating, irritability, and breast tenderness. EliLilly began marketing fl uoxetine hydrochloride as Sarafem in 2000 for treating PMDD. |
| Uses | antibacterial |
| Uses | Rivastigmine Metabolite |
Packaging And Shipping
Company Profile
Weijer International Trade (Hebei) Co., Ltd. is an enterprise located in Shijiazhuang, the capital of Hebei Province, China. We manufacture intermediates for several API’s falling under a wide range of therapeutic categories and also manufacture high-value fine chemicals & Specialty chemicals. Our products are sold all over the world (Europe, South America, North America, Southeast Asia, and Africa), and are highly praised by customers. Our company has reasonable prices and safe and efficient transportation methods, and has a strict quality management system and high-quality after-sales service, to meet the product and purchasing needs of new and old customers. Weijier also supports product customization.
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FAQ
1. How will you deliver the goods?
We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, and China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
2. How to start orders or make payments?
Proforma invoice will be sent first after confirmation of the order, enclosed our bank information. Payment by T/T, Western Union, L/C, Moneygram, BTC, Escrow.
3. How to contact us?
You can choose your interested products and send inquiry to us. You can chat with us via Trademanager, WhatsApp, and Skype Online. You can send us an email and you will receive our response.
4. How to confirm Product Quality before placing orders?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
5. How long is the lead time?
We deliver goods within 3 days for small order and 7-10 days for bulk order.
6. Is there any discount?
Yes, for larger quantity, we always support with better price.
Company Profile Introduction
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China- Since: 2017-04-05
- Address: Room 1304, Gaozhu Building, No. 3 Commercial Building, No. 210, Zhonghua North Street, Xinhua Distri
+86-15551193592
bruce@weijier.cn