Flufenamic acid NEW
| Price | $33 | $47 | $60 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Flufenamic acid | CAS No.: 530-78-9 |
| Purity: 99.71% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Flufenamic acid |
| Description | Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. |
| In vivo | Under peak amyloid fibril formation conditions (pH 4.4), Flufenamic acid binds to wild-type transthyretin (KD1=30 nM, KD2=255 nM), V30M transthyretin (KD1=41 nM, KD2=320 nM), and L55P transthyretin (KD1=74 nM, KD2=682 nM) with high affinity and negative cooperativity (pH value 7.6), fully inhibiting fibril formation at a concentration of 10.8 μM. In Xenopus oocytes, Flufenamic acid reversibly suppresses ICl(Ca) in a dose-dependent manner, with an IC50 of 28 mM, without affecting the shape of the current-voltage curve in response to depolarizing voltage. Flufenamic acid inhibits the calcium-activated non-selective cation channels in the basolateral membrane of rat pancreatic exocrine cells activated by an inward-outward patch with an IC50 of 10 μM. The compound also inhibits currents activated by intracellular ADP-ribose in recombinant human TRPM2 (hTRPM2) channels and the CRI-G1 rat insulinoma cell line. Additionally, it reversibly inhibits (IC50=13.8 μM) DAP and phase discharge in rat suprachiasmatic neurons with similar kinetics, without significantly affecting membrane potential, spike threshold, or input resistance (P > 0.05), nor does it significantly affect the frequency and amplitude of spontaneous synaptic potentials. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 28.1 mg/mL (100 mM) DMSO : 55 mg/mL (195.57 mM), Sonication is recommended. |
| Keywords | Flufenamic acid | Parasite | Cl? Channels | Ca channels | AMPK | Potassium Channel | Ca2+ channels | Cyclooxygenase | Inhibitor | inhibit | COX | Chloride Channel | AMP-activated protein kinase | KcsA | Calcium Channel |
| Inhibitors Related | Kaempferol | L-Ascorbic acid | Acetaminophen | Hydroxychloroquine | Metronidazole | Nitazoxanide | Doxycycline | Benzyl benzoate | Metformin hydrochloride | Paradol | Salicylic acid | Chitosan oligosaccharide |
| Related Compound Libraries | Anti-Parasitic Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | FDA-Approved Kinase Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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