Fluconazole NEW
| Price | $36 | $48 | $59 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-18 |
Product Details
| Product Name: Fluconazole | CAS No.: 86386-73-4 |
| Purity: 98.57% | Supply Ability: 10g |
| Release date: 2025/06/18 |
Product Introduction
Bioactivity
| Name | Fluconazole |
| Description | Fluconazole (UK-49858) is a triazole antifungal agent used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. |
| In vitro | Fluconazole significantly affects the fungicidal activity of 5-fluorocytosine against cryptococcal meningitis in mice. It is highly effective in extending the survival period of rats infected with representative Candida strains. Compared to the activity of each drug used alone, the combination of fluconazole with 5-fluorocytosine and amphotericin B exhibits markedly improved activity against cryptococcal meningitis. |
| In vivo | Under physiological pH conditions, Fluconazole's activity against 35 Candida albicans strains is 16-fold lower than that of Ketoconazole. When used in combination with Amphotericin B, Fluconazole exhibits synergistic effects against C. albicans cells, yet it does not alter the anti-biofilm activity of AmB. Fluconazole, alongside Caspofungin, antagonizes biofilm formation but has no effect on planktonic cells. Significantly, Fluconazole reduces ergosterol levels in C. albicans planktonic cells, leading to membrane perturbation. Its activity is less sensitive to acidic conditions compared to Ketoconazole. Additionally, the combined use of Fluconazole and Itraconazole shows effective activity against various Candida species, including Fluconazole-resistant strains of C. albicans and Candida tropicalis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 30.6 mg/mL (99.91 mM), Sonication is recommended. DMSO : 55 mg/mL (179.58 mM), Sonication is recommended. |
| Keywords | UK49858 | UK 49858 | Triazole | kefyr | Inhibitor | inhibit | fungi,Candida | Fungal | Fluconazole | Candida | C. albicans | Antifungal | Antibiotic | albicans | Agent | 14-α Demethylase |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Potassium gluconate | Ampicillin sodium | Doxycycline (hyclate) | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Penicillin G potassium | Geraniol | L-Citronellol |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Anti-Fungal Compound Library | Microbial Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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