FG 7142 NEW
| Price | $58 | $98 | $160 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: FG 7142 | CAS No.: 78538-74-6 |
| Purity: 98.81% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | FG 7142 |
| Description | FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). |
| In vitro | FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively. |
| In vivo | FG-7142, administered via intraperitoneal injection at doses of 15 mg/kg, enhances tyrosine hydroxylase activity and dopamine turnover specifically in the medial prefrontal cortex and ventral tegmentum, without impacting mesolimbic or nigrostriatal regions. At doses between 15-30 mg/kg, it stimulates mesolimbocortical dopaminergic projections, resulting in elevated dopamine levels in the prefrontal cortex and nucleus accumbens in rats. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (133.19 mM) |
| Keywords | nucleus accumben | inverse agonist | GABA Receptor | LSU 65 | dopaminergic | GABAA receptor | inhibit | Gamma-aminobutyric acid Receptor | FG-7142 | ZK39106 | LSU65 | ZK-39106 | FG 7142 | FG7142 | tyrosine hydroxylase | γ-Aminobutyric acid Receptor | Inhibitor |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | β-Alanine | Penicillin G sodium salt | Halothane | Valproic Acid | Chlorothymol | Piperazine citrate | Riluzole | Gabapentin | Nikethamide | (-)-α-Pinene |
| Related Compound Libraries | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 神經(jīng)退行性疾病化合物庫 | 抗阿爾茨海默癥化合物庫 | 膜蛋白靶向化合物庫 | 抗帕金森病化合物庫 | 神經(jīng)遞質(zhì)受體化合物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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