FCCP NEW
| Price | $36 | $51 | $92 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: FCCP | CAS No.: 370-86-5 |
| Purity: 99.5% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | FCCP |
| Description | FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer. |
| Cell Research | Protein synthesis rate is assayed in 24-mm diameter multi-well dishes with fresh medium containing 0.175 Ci/mmol of [3H]methionine (200 μM), for 30 min at 37°C. PC12 cells are treated with FCCP for different period of times. (Only for Reference) |
| In vitro | METHODS: Rat ventricular myocytes were treated with FCCP (10-1000 nM) for 1400 sec, and cellular oxygen consumption was measured using a Clark Oxygen Electrode. RESULTS: Oxygen consumption increased significantly, immediately, and in a dose-dependent manner after the addition of FCCP. [1] METHODS: Rat adrenal medullary chromaffinoma cells PC12 were treated with FCCP (30 μM) for 0.5-2 h. The rate of protein synthesis was measured using [3H]methionine. RESULTS: FCCP treatment produced a strong inhibition (68%) of protein synthesis rate for at least 2 hours. [2] |
| In vivo | METHODS: To test the effect on stroke, FCCP (1 mg/kg) was injected intraperitoneally into a C57BL/6J mouse model of stroke, followed by one hour of transient middle cerebral artery occlusion (tMCAO). RESULTS: Infarct volumes in the cortex, striatum, and whole hemisphere were significantly increased in mice pretreated with FCCP. Mice receiving FCCP had significantly increased neurologic deficit scores compared to carriers. [3] METHODS: To assay anti-tumor activity in vivo, FCCP (1 mg/kg) and cisplatin (2 mg/kg) were intraperitoneally injected every two days for two weeks into C57BL/6 mice harboring mouse ovarian epithelial carcinoma tumor ID8. RESULTS: The combination of FCCP and cisplatin inhibited tumor growth via OMA1-induced mitochondrial and ER stress. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.54 mg/mL (9.99 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 55 mg/mL (216.39 mM) |
| Keywords | inhibit | Mitochondrial Metabolism | Inhibitor | FCCP |
| Inhibitors Related | Imeglimin hydrochloride | Rotenone | Sodium oleate | trans-Aconitic acid | Phlorizin | Boscalid | α-Lipoic Acid | Lipoic acid | Chlorpropamide | D-Histidine | Revaprazan hydrochloride | Nerol |
| Related Compound Libraries | Cuproptosis Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1.00/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2024-06-13 | |
| $8.80/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2019-07-09 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY