(E/Z)-Polydatin NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: (E/Z)-Polydatin | CAS No.: 65914-17-2 |
| Purity: 99.29% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | (E/Z)-Polydatin |
| Description | (E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. |
| In vitro | In a study involving mice with sepsis induced by cecal ligation and puncture, polydatin (15/45/100 mg/kg) was found to inhibit the production of serum TNF-α and IL-6, the protein expression of lung cyclooxygenase-2 and inducible NO synthase isoforms, and the activation of NF-κB, thereby reducing mortality and lung injury in a dose-dependent manner. The LD50 of polydatin in mice was determined to be 1 g/kg (i.p.). |
| In vivo | Polydatin is a PLA2 inhibitor that reduces the expression of sPLA2-IIA mRNA and the activity of phospholipase A2. It also increases the expression of Clara cell secretory proteins, thereby mitigating lipopolysaccharide-induced lung injury. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (115.27 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | inhibit | cuspidatum | Inhibitor | Polygonum | (E/Z) Polydatin | (E/Z)Polydatin | (E/Z)-Polydatin |
| Related Compound Libraries | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Saccharide and Glycoside Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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