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Postion:Product Catalog >API>Antineoplastic agents>Hormonal antineoplastic drugs>Exemestane
Exemestane
  • Exemestane
  • Exemestane
  • Exemestane
  • Exemestane
  • Exemestane

Exemestane NEW

Price $25
Package 1box
Min. Order: 1box
Supply Ability: 100000box
Update Time: 2024-05-15

Product Details

Product Name: Exemestane CAS No.: 107868-30-4
EC-No.: 643-090-2 Min. Order: 1box
Purity: 99% Supply Ability: 100000box
Release date: 2024/05/15

Chinese name: Exemestane

English name :Exemestane

CAS number :107868-30-4

Molecular formula :C20H24O2

Molecular weight :296.4

EINECS number :643-090-2

Melting point :155.13°C

Boiling point :453.7±45.0 °C(Predicted)

Density :1.13± 0.1g /cm3(Predicted)

Storage conditions :2-8°C

Solubility: dimethyl sulfoxide: ≥20mg/mL

Form: Powder

Color: White to almost white

optical activity :[α]/D +250 to +300°, c = 1 in methanol

InChI: InChI = 1 s/C20H24O2 / c1-12-10-14-12-10-14-18 (22) 20 (15, 3) 9-7-16 (14), 19 (2), 9-7-16 (21) 11-17 (12) 19 / h6, 8,11,14-16 h, 1, 4-5,7,9-1 0 h2, 2-3 h3 / t14 -, 15 -, 16 -, 19 + 20 - / m0 / s1

InChIKey:BFYIZQONLCFLEV-DAELLWKTSA-N

SMILES:C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C

Use: Exemestane is a steroid aromatase inactivator, its structure is similar to the natural substrate of aromatase androstenedione, is the false substrate of aromatase

Synthesis: 6-methylene-androstene-4-ene-3, 17-dione (2) was synthesized from androstene-4-ene-3, 17-dione (3) by condensation with triethyl orthoformate, N-methylaniline and 40% formaldehyde solution, and then 1 was prepared by oxidation with 2, 3-dichloro-5,6 chemicalbook-dicyanoquinone (DDQ). Adding a certain amount of weak acid in oxidative dehydrogenation can shorten the reaction time from 15h to 8h, and the yield can be increased from 47% to 62%. The reaction conditions were mild, the separation was simple and the total yield was 45%.


Company Profile Introduction

Shanghai Getian Industrial Co.,Ltd is a leading enterprise committed to providing quality products and efficient logistics services. We are proud to introduce a range of products with excellent quality, and the industrial materials are subject to strict quality control to ensure that the high standards of our customers are met. We have pharmaceutical raw material production factory and reagent research and development center. We now have a complete product line. In addition, we have developed and produced tens of thousands of reagents. We are complemented by a custom synthesis business of various organic compounds. We can synthesize almost any chemical.

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  • Since: 2024-01-19
  • Address: Hong Kong
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