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Postion:Product Catalog >Ex26
Ex26
  • Ex26

Ex26 NEW

Price $113 $283 $455
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: Ex26 CAS No.: 1233332-37-0
Purity: 99.62% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱Ex26
描述Ex26 (S1P1-IN-Ex26) is a selective and potent sphingosine 1-phosphate receptor 1 (S1P1) antagonist that disrupts SR-B1-S1PR1 interactions and inhibits S1P-S1PR1 signaling. Ex26 is used in experimental autoimmune encephalomyelitis, atherosclerosis, and gastric cancer.
體外活性In U2OS cells and Chinese hamster ovary cells, Ex26 (0-10 μM; 1 hour) was confirmed as a potent and selective antagonist of S1P1 (IC50=0.93 nM)[1].
體內(nèi)活性In eight-week-old male C57Bl/6J mice, S1P1-IN-Ex26 (3 mg/kg; intraperitoneal injection; once daily; 3 days) induced lymphocyte sequestration at low doses, with an ED50 of 0.06 mg/kg after 2 hours of treatment. This led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen[1].
存儲條件store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
關(guān)鍵字S1P1INEx26 | S1P1 IN Ex26 | S-1P1-IN-Ex26
相關(guān)產(chǎn)品Fingolimod hydrochloride | SLP9101555 | SKI-178 | LX-2931 | K145 hydrochloride | ASP-4058 | Ceranib-2 | Siponimod | MP-A08 | Ozanimod
相關(guān)庫經(jīng)典已知活性庫 | 已知活性化合物庫 | GPCR靶點分子庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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