Euphorbia factor L1 NEW
| Price | $100 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Euphorbia factor L1 | CAS No.: 76376-43-7 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Euphorbia factor L1 |
| 描述 | Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects. |
| 細(xì)胞實驗 | 3T3‐L1 cells were treated with euphorbiasteroid at concentrations of 6.25, 12.5, 25 and 50?μM for 2?days in adipogenesis induction medium, 2?days in adipogenesis medium and 2?days in culture medium (CM) sequentially during differentiation. Intracellular triglycerides (TGs) were stained with Oil red O (ORO) solution. |
| 體外活性 | Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of euphorbiasteroid could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway[1]. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells[2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Methanol : Soluble DMSO : 37 mg/mL (66.9 mM) Ethanol : Soluble |
| 關(guān)鍵字 | Euphorbia factor L-1 | Euphorbia factor L1 |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Myricetin | Meclizine dihydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | Salicylic acid | Oleic acid |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 萜類天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 膜蛋白靶向化合物庫 | 植物來源化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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