Product Details
| Product Name:
Epoxyazadiradione |
CAS No.:
18385-59-6 |
| Purity:
99.29% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Epoxyazadiradione |
| 描述 | Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells. |
| 體外活性 | Epoxyazadiradione exhibits most potent anti-cancer activity in both TNBC and ER+ breast cancer cells.?Epoxyazadiradione induces apoptosis and inhibits PI3K/Akt-mediated mitochondrial potential, cell viability, migration and angiogenesis.?It also inhibits the expression of pro-angiogenic and pro-metastatic genes such as Cox2, OPN, VEGF and MMP-9 in these cells.?Furthermore, epoxyazadiradione attenuates PI3K/Akt-mediated AP-1 activation.Epoxyazadiradione suppresses breast tumor growth and angiogenesis in orthotopic NOD/SCID mice model. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/ml (128.6 mM)
|
| 關(guān)鍵字 | huMIF | Parasite | Inhibitor | proinflammatory | MIF | Epoxyazadiradione | limonoid | inhibit | parasites |
| 相關(guān)產(chǎn)品 | Quinoclamine | Sodium 4-aminosalicylate dihydrate | Sulfasalazine | Lidocaine | Diethylmaleate | sodium lauroyl-α-hydroxyethyl sulfonate | WITHAFERIN A | Lidocaine hydrochloride | Parthenolide | Pyrrolidinedithiocarbamate ammonium | Sodium salicylate | Bortezomib |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 植物來源化合物庫 | 天然產(chǎn)物庫 | 抗寄生蟲天然產(chǎn)物庫 | 抑制劑庫 | 高通量篩選天然產(chǎn)物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1500.00/10mg |
VIP1Y
|
R&D Scientific Inc.
|
2024-03-31 |
United States