Eplerenone NEW
| Price | $44 | $63 | $127 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-16 |
Product Details
| Product Name: Eplerenone | CAS No.: 107724-20-9 |
| Purity: 99.75% | Supply Ability: 10g |
| Release date: 2025/06/16 |
Product Introduction
Bioactivity
| Name | Eplerenone |
| Description | Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase levels, but has yet to be linked to cases of clinically apparent drug induced liver disease. |
| In vitro | Eplerenone increases total vascular and luminal areas in swine without affecting the endothelial area. In canine models, it significantly reduces left ventricular end-diastolic wall stress. Eplerenone attenuates the rise in pulse pressure due to aldosterone (Aldo) in rats, normalizing the wall stress curve, mean cross-sectional area, and EIIIA fibronectin levels in Aldo-salt hypertensive rats. The compound upregulates diminished endothelial nitric oxide synthase mRNA in Dahl salt-sensitive hypertensive (DS) rats, markedly improving glomerulosclerosis and proteinuria. In mice, daily administration of 200 mg/kg of Eplerenone significantly lowers systolic and diastolic blood pressures compared to controls and increases serum phosphatase activity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 4.1 mg/mL (9.89 mM), Sonication is recommended. |
| Keywords | specific | SC66110 | SC 66110 | MRA | Mineralocorticoid Receptor | Inhibitor | inhibit | hypertension | GlucocorticoidReceptor | Glucocorticoid Receptor | Eplerenone | Endogenous Metabolite | chronic systolic heart failure (HF) | CGP-30083 | CGP30083 | cardiovascular (CV) | atherosclerosis | aldosterone |
| Inhibitors Related | Nimodipine | Hydrocortisone | Mifepristone | Prednisone | Prednisolone acetate | Cortisone | Dexamethasone acetate | Dexamethasone | Dexamethasone Phosphate disodium | Prednisone acetate | Desonide | Corticosterone |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Drug-induced Liver Injury (DILI) Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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