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Postion:Product Catalog >API>Hormones and the Endocrine System>Pancreatic hormone and blood sugar regulation>Epalrestat
Epalrestat
  • Epalrestat

Epalrestat

Price Get Latest Price
Package 1kg
Min. Order: 1kg
Supply Ability: 20tons
Update Time: 2023-09-14

Product Details

Product Name: Epalrestat CAS No.: 82159-09-9
EC-No.: 675-018-0 Min. Order: 1kg
Purity: 99.87% Supply Ability: 20tons
Release date: 2023/09/14

Application

  1. Diabetic Neuropathy: Epalrestat is primarily used in the treatment of diabetic neuropathy. Diabetic neuropathy is a common complication of diabetes that affects the nerves, causing symptoms such as pain, numbness, and tingling in the extremities. Epalrestat helps to reduce the accumulation of sorbitol, a sugar alcohol, in nerve cells, which is believed to contribute to the development of diabetic neuropathy. By inhibiting aldose reductase, an enzyme involved in sorbitol synthesis, Epalrestat can alleviate symptoms and slow the progression of diabetic neuropathy.

  2. Aldose Reductase Inhibitor: Epalrestat is a potent aldose reductase inhibitor. Aldose reductase is an enzyme that converts glucose into sorbitol. Excessive sorbitol accumulation can lead to cellular damage, particularly in tissues with limited sorbitol metabolism, such as the nerves, eyes, and kidneys. By inhibiting aldose reductase, Epalrestat helps to reduce sorbitol levels and prevent the associated tissue damage.

  3. Ocular Disorders: Epalrestat has been investigated for its potential use in various ocular disorders, such as diabetic retinopathy and cataracts. Diabetic retinopathy is a complication of diabetes that affects the blood vessels in the retina, leading to vision problems and, in severe cases, blindness. Epalrestat's aldose reductase inhibitory effects may help to mitigate the progression of diabetic retinopathy. Additionally, by reducing oxidative stress and sorbitol accumulation, Epalrestat may have a protective effect against cataract formation.

  4. Nerve Regeneration: Some studies suggest that Epalrestat may have a role in promoting nerve regeneration. It has been shown to enhance nerve growth factor synthesis and nerve fiber regeneration in animal models of peripheral nerve injury. This potential neurotrophic effect of Epalrestat could have implications in the treatment of nerve injuries and related conditions.

  5. Anti-inflammatory Effects: Epalrestat has demonstrated anti-inflammatory properties in preclinical studies. It can inhibit the production of pro-inflammatory cytokines and the activation of nuclear factor-kappa B (NF-κB), a transcription factor involved in inflammatory processes. These anti-inflammatory effects may be beneficial in conditions characterized by chronic inflammation, such as diabetic complications.

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Company Profile Introduction

Wuhan Hansheng New Material Technology Co.Ltd founded in 2022. our company mainly supply steroid raw powders,sarms raw powders,fat burner raw powders,peptides, food addtives, API raws,Cosmetics raw powders.veterinary raw powders. Our company is a professional manufacturer leading factory in China in pharmaceutical area for many years, our products have exported to USA,Greece, Spain, UK, Germany, Australia and other countries, and we have got very good feedback from our customers, we had established a long term friendly relations with our customers all over the world, and in some area like Europe and North America, we have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. High quality, best price, first-class service, high successful delivery rate, we have stock, so we can delivery quickly at the very day when payment is arrived.

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  • Since: 2022-09-29
  • Address: Room 401, 4th Floor, No. 3-1 Factory Building, Guandong Science and Technology Industrial Park, Jiay
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