Enoxacin NEW
| Price | $34 | $45 | $63 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Enoxacin | CAS No.: 74011-58-8 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Enoxacin |
| 描述 | Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. |
| 體外活性 | Enoxacin, a fluoroquinolone used as an antibacterial compound, enhances the production of miRNAs with tumor suppressor functions by binding to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP). [1] Enoxacin binds to the DNA active site and alters the breakage/reunion activity of the enzyme. Enoxacin stimulates cleavage of both relaxed and supercoiled forms of DNA in the absence of ATP, whereas CcdB induces cleavage only after many cycles of ATP-dependent breakage and reunion. [2] Enoxacin dose dependently reduces the number of osteoclasts differentiating in mouse marrow cultures stimulated with 1,25-dihydroxyvitamin D(3), as well as markers of osteoclast activity, and the number of resorption lacunae formed on bone slices. Enoxacin inhibits osteoclast formation at concentrations where osteoblast formation is not altered. [3] Enoxacin dose-dependently reduces the number of multinuclear cells expressing tartrate-resistant acid phosphatase (TRAP) activity produced by RANK-L-stimulated osteoclast precursors. Enoxacin directly inhibits osteoclast formation without affecting cell viability by a novel mechanism that involves changes in posttranslational processing and trafficking of several proteins with known roles in osteoclast function. [4] Enoxacin is able to decrease cell viability, induce apoptosis, cause cell cycle arrest, and inhibit the invasiveness of prostate cancer (PCa) cell lines. Enoxacin is also effective in restoring the global expression of miRNAs in prostate cancer (PCa) cell lines. [5] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 60 mg/mL (187.31 mM) |
| 關(guān)鍵字 | gram-negative | DNA/RNA Synthesis | Bacterial | DNA | miRNA | inhibit | Inhibitor | mRNA | CI-919 | gram-positive | AT-2266 | TAR-RNA | siRNA | NSC-629661 | NSC629661 | TRBP | CI919 | MicroRNA | Antibiotic | Enoxacin | AT2266 | gyrase | topoisomerase |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Kanamycin sulfate | Sulfamethoxazole sodium | Guanidine hydrochloride | Doxycycline | Thymidine | Dimethyl sulfoxide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗病毒庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | FDA 上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $34.00/25mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-17 | |
| $50.00/1kg |
Henan Bao Enluo International TradeCo.，LTD
|
2023-07-10 | ||
| $0.00/25kg |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2023-05-15 | |
| $33.00/1kg |
Hebei baicao biology science and technology co., ltd
|
2022-04-06 | ||
| $19.63/1Kg/Bag |
Hong Kong Tiansheng New Material Trading Co., Ltd
|
2022-01-07 | ||
| $220.00/25Kg/Drum |
VIP5Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2021-10-19 | |
| $1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-07-19 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
| $1.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2018-08-20 | |
| $40.99/1KG |
Hong Kong Tiansheng New Material Trading Co., Ltd
|
2021-12-29 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY