Endothelin-2 (49-69), human NEW
| Price | $198 | $427 | $592 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Endothelin-2 (49-69), human | CAS No.: 123562-20-9 |
| Purity: 98.26% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Endothelin-2 (49-69), human |
| Description | Endothelin-2 (49-69), human (Human endothelin-2), is a 21-amino-acid vasoactive peptide that binds to G-protein-coupled receptors ET-RA and ET-RB. |
| In vitro | At nanomolar concentrations, Endothelin-2 significantly induces strong and persistent vasoconstriction, similar to the effects observed with other endothelins (EC50=0.52 nM)[1]. It functions as a potent chemoattractant specifically for macrophages and THP-1 monocytic cells, but does not attract freshly isolated monocytes. The chemotactic activity towards Endothelin-2 demonstrates a characteristic bell-shaped curve. Research utilizing endothelin receptor antagonists has revealed that the ET-RB receptor mediates the directed cell migration towards Endothelin-2. Moreover, the presence of Endothelin-2 in tumor environments suggests it plays a role in modifying macrophage behavior, leading to the accumulation of activated macrophages in hypoxic regions. |
| In vivo | Rats[1] For the assay of pressor activity, male Wistar rats weighing 300-350 g are anesthetized with urethane (1 g/kg i.p.) and pretreated with atropine (0.25 mg/kg i.v.), propranolol (1 mg/kg i.v.), and bunazocine (1 mg/kg i.v.). Additional maintenance doses (one-half of the initial doses) of the autonomic blockades are administered every 3-4 hr. Each animal is given only one bolus of Endothelin-2. 1 nM of Endothelin-2 in 50 渭L of buffer is bolus injected from a cannula inserted in the right femoral vein. The blood pressure is recorded from a cannula, which is placed in the right carotid artery and connected to a pressure transducer[1]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : Soluble |
| Keywords | peptide | Endothelin-2 , human | 21-amino | inhibit | Human endothelin 2 | vasoactive | acid | ET-RB | Endothelin 2 (49 69), human | Endothelin2 (4969), human | Human endothelin2 | ET-RA | Endothelin-2 | Inhibitor | transmembrane |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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