Eltanexor NEW
| Price | $60 | $108 | $237 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Eltanexor | CAS No.: 1642300-52-4 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Eltanexor |
| 描述 | Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines. |
| 體外活性 | Eltanexor (KPT-8602) (1 nM; 16 hours) causes apoptosis in leukemia cell lines. KPT-8602 (2-6 nM; 72 hours) decreases cell viability in leukemia cell lines (EC50s ranging from 25 to 145 nM). |
| 體內(nèi)活性 | KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) demonstrates potent anti-lymphoblastic leukemia activity. |
| 存儲(chǔ)條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 80 mg/mL (186.78 mM) H2O : < 0.1 mg/mL (insoluble) |
| 關(guān)鍵字 | ONO7706 | Eltanexor | ATG 016 | ONO 7706 | KPT 8602 | KPT8602 | ATG016 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | ReFRAME 相關(guān)化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $196.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $60.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-12 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY