Ellagic acid NEW
| Price | $44 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Ellagic acid | CAS No.: 476-66-4 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | Ellagic acid |
| Description | Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity. |
| In vitro | METHODS: Human pancreatic cancer cell lines PANC-1, AsPC-1 and MIA PaCA-2 were treated with Ellagic acid (10-1000 μM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: The proliferation of PANC-1 was inhibited by the addition of 10 μM Ellagic acid in a dose-dependent manner. The proliferation of AsPC-1 was inhibited by the addition of 100 μM Ellagic acid, while the proliferation of MIA PaCA-2 was inhibited only by the addition of 1000 μM Ellagic acid. [1] METHODS: Human lung cancer cells A549 were treated with Ellagic acid (5-20 μM) for 48 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Ellagic acid treatment significantly down-regulated the phosphorylation of PI3K and Akt in a dose-dependent manner. [2] |
| In vivo | METHODS: To investigate the hepatoprotective effects on alcohol-induced liver disease (ALD), Ellagic acid (50-100 mg/kg suspended in 0.5% CMC-Na) was administered by gavage once daily for four weeks to ICR mice receiving 50% (v/v) alcohol orally daily. RESULTS: Ellagic acid attenuated oxidative stress, inflammatory response, steatosis and gut microbiota dysbiosis in ALD mice. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.02 mg/mL (10 mM), Sonication is recommended. |
| Keywords | inhibit | Inhibitor | Casein Kinase | Reactive Oxygen Species | Endogenous Metabolite | Ellagic acid |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Oleamide | Glycerol | Thymidine | Naringin |
| Related Compound Libraries | 中藥單體化合物庫 | 激酶抑制劑庫 | 中藥抗炎分子庫 | 抑制劑庫 | 抗寄生蟲天然產(chǎn)物庫 | 微生物天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 抗衰老化合物庫 | 化妝品成分化合物庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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