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Postion:Product Catalog >Eflornithine hydrochloride hydrate
Eflornithine hydrochloride hydrate
  • Eflornithine hydrochloride hydrate

Eflornithine hydrochloride hydrate NEW

Price $42 $124
Package 100mg 500mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Eflornithine hydrochloride hydrate CAS No.: 96020-91-6
Purity: 99.64% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameEflornithine hydrochloride hydrate
DescriptionEflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific and irreversible inhibitor of the ornithine decarboxylase (ODC). Eflornithine hydrochloride hydrate has antitumor activity and has also been used in the hirsutism Eflornithine hydrochloride hydrate has antitumor activity and is also used in the treatment of hirsutism.
Cell ResearchBY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)
In vitroWhen cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].
In vivoEflornithine stands as the only novel compound registered for human African trypanosomiasis treatment in the past five decades, primarily serving as an alternative for cases resistant to melarsoprol involving Trypanosoma brucei gambiense. Additionally, a 15% eflornithine cream demonstrates efficacy superior to placebo in diminishing excessive, unwanted facial hair growth in patients, with 58% of individuals treated with eflornithine observing at least some improvement in facial hirsutism after 24 weeks, compared to 34% of those receiving placebo. Furthermore, the inhibitory effect on hair growth by eflornithine cream is significantly amplified when applied to mouse skin previously treated with microneedles. In hypertensive rats with coarctation, eflornithine treatment normalizes contractile responses to KCI and norepinephrine, and enhances relaxations to acetylcholine within 14 days, indicating its broader pharmacological utility.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 55 mg/mL (232.42 mM)
Keywordsinhibit | DFMO hydrochloride | α-difluoromethylornithine hydrochloride | α-difluoromethylornithine hydrochloride Hydrate | RMI-71782 hydrochloride Hydrate | Eflornithine hydrochloride Hydrate | Eflornithine Hydrochloride | Eflornithine hydrochloride hydrate | MDL-71782 hydrochloride Hydrate | Inhibitor | a-difluoromethylornithine hydrochloride Hydrate | Difluoromethylornithine hydrochloride Hydrate | MDL-71782 hydrochloride | RMI-71782 hydrochloride | Parasite | DFMO hydrochloride Hydrate
Inhibitors Relatedα-Hydroxyglutaric Acid Lithium | Carbidopa monohydrate | L-Ornithine | Carbidopa | 4-Bromo-3-hydroxybenzoic acid | Tritoqualine
Related Compound LibrariesHighly Selective Inhibitor Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Metabolism Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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