天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antiviral drugs>Efavirenz
Efavirenz
  • Efavirenz

Efavirenz NEW

Price $35 $48 $65
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Efavirenz CAS No.: 154598-52-4
Purity: 99.83% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameEfavirenz
DescriptionEfavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor, acting as a Non-Nucleoside Reverse Transcriptase Inhibitor, Cytochrome P450 3A Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C9 Inhibitor, Cytochrome P450 2C19 Inhibitor, and Cytochrome P450 3A4 Inhibitor, classified as a Non-Nucleoside Analog.
Cell ResearchThe OCR(O2 consumption rate) is measured in SH-SY5Y and U-251 mg cells exposed to vehicle, 10 μM efavirenz or 25 μM efavirenz for 1 h. (Only for Reference)
Kinase AssayRecombinant RT enzymes are expressed, purified, and assessed for inhibition by Efavirenz (L-743726). Ki and Kii values are determined for each enzyme tested. The wild-type RT exhibited exclusively noncompetitive inhibition kinetics (data not shown), and, therefore, the Ki and Kii values are identical. Pure noncompetitive inhibition is not assumed for the mutant enzymes, and, hence, the values of both Ki and Kii are obtained from the linear mixed-type inhibition equation. The two- to threefold differences between the Ki and Kii values probably reflect a small contribution of competitive inhibition with the mutant RTs[1].
In vitroEfavirenz has direct inhibitory effect on the mitochondrial respiratory function of cultured glioblastoma and differentiated neuroblastoma cell lines[2]. ER stress markers, including CHOP and GRP78 expression (both protein and mRNA), phosphorylation of eIF2a, and presence of the spliced form of XBP1 are upregulated. Efavirenz also enhances cytosolic Ca2+ content and induced morphological changes in the ER suggestive of ER stress. This response is greatly attenuated in cells with altered mitochondrial function (Rho). The effects of Efavirenz on the ER, and particularly in regard to the mitochondrial involvement, differs from those elicited by a standard pharmacological ER stressor[3].
In vivoEfavirenz leads to arterial stiffening but, for the dose and duration tested, did not lead to elevated plaque progression in ApoE(-/-) mice[4].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationMethanol : 10 mM
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 60 mg/mL (190.07 mM)
KeywordsHIV | inhibit | DMP-266 | Autophagy | Human immunodeficiency virus | L 743726 | Inhibitor | Efavirenz | L743726 | DMP266 | Reverse Transcriptase
Inhibitors RelatedStavudine | Emtricitabine | Hydroxychloroquine | Guanidine hydrochloride | Lamivudine | Paeonol | Naringin
Related Compound LibrariesBioactive Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$0.00/200kg
VIP6Y
Hebei Weibang Biotechnology Co., Ltd
2024-10-31
$0.00/1kg
VIP1Y
Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-05-07
$15.00/1kg
Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-28
$0.00/25kg
PNP Biotech Co. Ltd
2023-07-12
$0.00/25KG
VIP5Y
Hebei Mojin Biotechnology Co., Ltd
2023-07-04
$100.00/1ml
Shijiazhuang Gantuo Biotechnology Co., Ltd
2023-03-10
$200.00/1kg
Hebei Mingeng Biotechnology Co., Ltd
2022-11-24
$0.00/1Kg/Bag
VIP4Y
Sinoway Industrial co., ltd.
2022-09-16
$32.00/1KG
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
2021-12-16
$15.00/1KG
Qiuxian Baitai New Material Co., LTD
2021-11-26
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
INQUIRY