Echinatin NEW
| Price | $31 | $64 | $113 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-11 |
Product Details
| Product Name: Echinatin | CAS No.: 34221-41-5 |
| Purity: 98.12% | Supply Ability: 10g |
| Release date: 2025/06/11 |
Product Introduction
Bioactivity
| Name | Echinatin |
| Description | Echinatin (Retrochalcone) is extracted from licorice and is a natural chalcone. Echinatin has a wide range of biological activities including hepatoprotective, anti-inflammatory, anti-bacterial infections, and attenuates lung damage. |
| In vitro | METHODS: Esophageal squamous cell carcinoma cells KYSE30 and KYSE270 were treated with Echinatin (10-40 μM) for 1-5 days and cell viability was measured by CCK-8 assay. RESULTS: Echinatin significantly inhibited cell proliferation in a dose- and time-dependent manner. [1] METHODS: Human osteosarcoma cells 143B and MG63 were treated with Echinatin (30-50 μM) for 24 h. Cell cycle was measured by Flow cytometry. RESULTS: Echinatin significantly increased the percentage of osteosarcoma cells in the S phase of the cell cycle. [2] |
| In vivo | METHODS: To test the antitumor activity in vivo, Echinatin (20-50 mg/kg) was administered by gavage to nude mice bearing KYSE270 xenografts every two days for 14 days. RESULTS: Tumor load was significantly suppressed, with a 57% and 48% reduction in the groups treated with 20 and 50 mg/kg Echinatin, respectively.Echinatin inhibited the AKT/mTOR pathway, as evidenced by a reduction in the expression levels of p-AKT and p-mTOR. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.9 mg/mL (18.13 mM), Solution. Chloroform : Soluble DMSO : 20 mg/mL (74 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | Freeradicalscavengers | Free radical scavengers | Echinatin |
| Inhibitors Related | Tempo | Cycloolivil | Sodium 4-aminosalicylate dihydrate | Rubiadin | AFMK | Edaravone | Maclurin | Retusin | Peonidin-3-O-glucoside chloride | Isomangiferin | Rebamipide | Cyclo(L-Phe-L-Pro) |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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