Ebastine NEW
| Price | $47 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ebastine | CAS No.: 90729-43-4 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ebastine |
| Description | Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness. |
| In vivo | Compared to H2 receptors, Ebastine showed selectivity for histamine H1, moderate activity against other potential mediators of allergic phenomena such as leukotriene C4 and platelet-activating factor, and was apparently effective in targeting allergic reaction antigens induced by exposure of appropriately sensitized tissues or animals to allergies.Ebastine inhibited, in human nasal polyp cells, anti-IgE-induced prostaglandin D2 and leukotriene C4/D4 with IC30 of 2.57 μM and 9.6 μM, respectively, and inhibited cytokine release.Ebastine also inhibited hERG-expressing IKr in African Xenopus oocytes with a Kd value of 0.3 μM, with a maximal inhibition of 46% at 3 μM.Ebastine exerted a small effect on transient potassium currents in rats at a concentration of less than 100 nM. Ebastine had a small effect on the transient potassium current in rats at concentrations less than 100 nM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 4.69 mg/mL (10 mM) |
| Keywords | Inhibitor | LAS-W090 | RP-64305 | antiallergic | urticaria | rhinitis | Histamine Receptor | antihistamine | idiopathic | RP 64305 | LAS-W-090 | inhibit | allergic | Ebastine |
| Inhibitors Related | Chlorphenesin | Meclizine dihydrochloride | Mirtazapine | Lidocaine | Famotidine | Mebhydrolin napadisylate | Amitriptyline hydrochloride | Alginic acid | Trazodone hydrochloride | Mianserin hydrochloride |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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