(E)-Ferulic acid NEW
| Price | $53 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-29 |
Product Details
| Product Name: (E)-Ferulic acid | CAS No.: 537-98-4 |
| Purity: 99.63% | Supply Ability: 10g |
| Release date: 2025/04/29 |
Product Introduction
Bioactivity
| Name | (E)-Ferulic acid |
| Description | (E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.t(E)-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. |
| Cell Research | The 2,2-diphenyl-1-picrylhydrazyl assay was used to determine free radical scavenging capability. Assessment of intracellular reactive oxygen species (ROS) was evaluated using oxidized 2',7'-dichlorofluorescin diacetate and dihydroethidium staining. Trypan blue exclusion, colony formation, and anchorage-independent growth assays were used to determine cellular proliferation. Annexin V staining assay was used to assess cellular apoptosis by flow cytometry. Wound healing and Boyden's well assays were used to detect the migration and invasion of cells. Gelatin zymography was used to detect matrix metalloproteinase (MMP-2 and MMP-9) activity. Western blotting was used to detect expression levels of various signaling pathway proteins. |
| In vitro | trans-Ferulic acid exerted potent antioxidant effects. However, trans-Ferulic acid increased intracellular ROS levels, including hydrogen peroxide and superoxide anion, in H1299 cells. trans-Ferulic acid treatment inhibited cellular proliferation and induced moderate apoptotic cell death at the highest concentration used (0.6 mM). Furthermore, trans-Ferulic acid moderately inhibited the migration of H1299 cells at the concentrations of 0.3 and 0.6 mM and attenuated MMP-2 and MMP-9 activity. trans-Ferulic acid caused the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin. Conversely, trans-Ferulic acid treatment increased the expression of pro-apoptotic factor Bax and decreased the expression of pro-survival factor survivin. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 65 mg/mL (334.74 mM), Sonication is recommended. |
| Keywords | β-catenin | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | Inhibitor | inhibit | Ferulic acid | Ferroptosis | EndogenousMetabolite | Endogenous Metabolite | Coniferic acid | beta-catenin | betacatenin | Beta catenin | Bcl-2 Family | bcatenin | Bax | (E)-Ferulic acid | (E)Ferulic acid | (E) Ferulic acid |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Colorectal Cancer Compound Library | Ferroptosis Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Neural Regeneration Compound Library | Traditional Chinese Medicine Monomer Library | Cancer Cell Differentiation Compound Library | Anti-Ovarian Cancer Compound Library | Neuroprotective Compound Library | Anti-Aging Compound Library | Traditional Mongolian Medicine Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $10.00/1KG |
VIP7Y
|
Hebei Chuanghai Biotechnology Co., Ltd
|
2024-11-29 | |
| $79.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co Ltd
|
2024-11-20 | |
| $10.00/1kg |
Ouhuang Engineering Materials (Hubei) Co., Ltd
|
2024-04-23 | ||
| $0.00/1kg |
VIP2Y
|
Hebei Kingfiner Technology Development Co.Ltd
|
2023-05-26 | |
| $0.00/20mg |
VIP4Y
|
Changsha Staherb Natural Ingredients Co., Ltd.
|
2022-10-20 | |
| $0.00/1KG |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-09 | |
| $10.00/1Kg/Bag |
Hebei Zhanyao Biotechnology Co. Ltd
|
2021-10-28 | ||
| $100.00/25KG |
VIP5Y
|
Hebei Mujin Biotechnology Co.,Ltd
|
2021-10-09 | |
| $10.00/1ASSAYS |
Shanxi Naipu Import and Export Co.,Ltd
|
2021-09-26 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY