Dutasteride  CAS 164656-23-9

Dutasteride (GG745) is a potent inhibitor of both 5 alpha-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.IC50 Value:Target: 5 alpha-reductasein vitro: Dutasteride inhibited (3)H-T conversion to (3)H-DHT and, as anticipated, inhibited T-induced secretion of PSA and proliferation. However the drug also inhibited DHT-induced PSA secretion and cell proliferation (IC(50) approximately 1 microM). Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 microM. High concentrations of dutasteride (10-50 microM), but not finasteride, in steroid-free medium, resulted in enhanced cell death, possibly by apoptosis [1]. Dutasteride reduces cell viability and cell proliferation in both cell lines tested (androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer (PCa)) [2].in vivo: GG745 has a terminal half-life of approximately 240 hr, and single doses of >10 mg decreased DHT levels significantly more than did single 5-mg doses of finasteride [3]. In placebo treated men without prostate cancer there was an 8.3% median increase in PSA at month 24 compared with -59.5% in those who received dutasteride, using doubled values to correct for dutasteride treatment [4].Toxicity: Dutasteride may affect male fertility and steroid hormone dynamics. Therefore, a 21-day reproduction study was conducted to determine the effects of dutasteride (10, 32 and 100 μg/L) on fish reproduction. Exposure to dutasteride significantly reduced fecundity of fish and affected several aspects of reproductive endocrine functions in both males and females [5].Clinical trial: Bioequivalence Study Of Dutasteride Five 0.1 mg And One 0.5 mg Soft Gelatin Capsules In Healthy Male Volunteers.

Company Introduction

Hebei Best Biological Technology Co., Ltd. is a modern advanced enterprise specializing in production and exportation of APIs,Pharmaceutical intermediates, peptides, plant extracts etc. Our products are widely used in medicine, health care products,cosmetics, nutritional supplements and food additives areas.

Why Choose Us

1. Rich experience

We specialize in this filed for many years, our steriods and hormones exported to all over the world and established long friendly relations of cooperation with them.

2. Great quality,purity and favorable

Good quality is one of our biggest secret to success; you can get the best quality and service from us.

3. Safest and fastest delivery

We have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment. Fast and discreet shipment will be arranged to pass customs.

4. Good package

Unique ways to ship 10g to 100kg powders to your destination. We offer melting powder into liquid service and ship the liquid in special bottles.

5. Great after-sales service

Any needs or questions contact me freely.

FAQ

Q1: What is your MOQ?

A:Our MOQ is 10g, 100g and 1kg for your evaluation quality of our goods on the condition that sample charge is 100% paid.

Q2: Is there any discount?

A:Yes, for larger quantity, we always support with better price.

Q3: What payment terms do you accept ?

A:We'd like to accept T/T, L/C, Paypal, or Western Union.

Q4: How long will it take to get the goods?

A:Depending on your location, For small order, please expect 5-7 days by DHL, UPS, TNT, FEDEX, EMS. For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q5: How do you treat quality complaint?

A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6: How can we trust you?

A: You are always warmly welcomed to visit us at any time. Before we start B2B, MIC has audited our company on-spot and approved our credit.

Q7: Do you test all your goods before delivery?

A: Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.

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