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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Metabolism>Carbonic Anhydrase Inhibitors>Dorzolamide hydrochloride
Dorzolamide hydrochloride
  • Dorzolamide hydrochloride

Dorzolamide hydrochloride NEW

Price $35 $48 $68
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Dorzolamide hydrochloride CAS No.: 130693-82-2
Purity: ≥95% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameDorzolamide hydrochloride
DescriptionDorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis.
In vitroIn rabbits, Dorzolamide hydrochloride significantly reduces intraocular pressure (IOP) and is effective at night as well. Dorzolamide substantially decreases IOP in glaucoma-afflicted monkeys by 22%, 30%, and 37%. The combination of Dorzolamide (administered topically to the eye for 1 to 5 days) and oral methazolamide (administered from day 3 to day 5) significantly lower IOP, with this effect persisting on days 1, 3, and 5. Compared to the regimen of twice-daily oral methazolamide and 2% Dorzolamide, applying Dorzolamide (2%) topically three times a day achieves a similar reduction in IOP.
In vivoDorzolamide induces dilation of retinal blood vessels through three distinct mechanisms that directly cause precontraction, independent of extracellular pH changes. It acts as a potent inhibitor of carbonic anhydrase (CA) II, penetrating the sclera and cornea to reach the ciliary processes and reduce the formation of HCO3 and aqueous humor.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 13.3 mg/mL (36.9 mM)
DMSO : 1 mg/mL (2.77 mM)
Keywordstumor | solid | MK-507 Hydrochloride | MK507 Hydrochloride | MK-507 | MK507 | MK 507 Hydrochloride | MK 507 | L-671152 Hydrochloride | L671152 Hydrochloride | L-671152 | L671152 | L 671152 Hydrochloride | L 671152 | Inhibitor | inhibit | EAC | Dorzolamide Hydrochloride | Dorzolamide hydrochloride | Dorzolamide | Carbonic Anhydrase | Carbonate dehydratase | CA-II | anti-tumor
Inhibitors RelatedBenzenesulfonamide | Urea | Cyclamic acid sodium | Hydrochlorothiazide | Orthanilamide | Tioxolone | Zonisamide | Histone acetyltransferase p300 Inhibitor 4c | EMAC10101d | pNNP | Levosimendan | Trichlormethiazide
Related Compound LibrariesFDA-Approved & Pharmacopeia Drug Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Metabolism Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Metabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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