DJ-V-159 NEW
| Price | $30 | $48 | $79 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: DJ-V-159 | CAS No.: 2253744-53-3 |
| Purity: 99.96% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | DJ-V-159 |
| Description | DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A). |
| In vitro | DJ-V159 activates ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. Additionally, DJ-V159 dose-dependently stimulates cAMP production in GPRC6A-expressing HEK-293 cells at 0.2 nM concentrations in the media. DJ-V159 also stimulates insulin secretion in mouse beta-cell MIN-6 cells, with an insulin stimulation index (SI) similar to Ocn, a known ligand of GPRC6A [1]. |
| In vivo | DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice at 60 and 90 minutes, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 5.02 mg/mL (10 mM) |
| Keywords | DJV159 | DJ-V-159 | Inhibitor | Androgen Receptor | inhibit | DJ V 159 | DJ-V 159 |
| Inhibitors Related | Vincamine | Dehydroisoandrosterone 3-acetate | Bicalutamide | Monomethyl fumarate | S-23 | Bavdegalutamide | Enzalutamide | Benzyl nicotinate | Allura Red AC | Sunset Yellow FCF | Ostarine | Flutamide |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | NO PAINS Compound Library | Anti-Prostate Cancer Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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