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Postion:Product Catalog >DHODH-IN-15
DHODH-IN-15
  • DHODH-IN-15

DHODH-IN-15 NEW

Price $117 $268 $395
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: DHODH-IN-15 CAS No.: 1364791-88-7
Purity: 97.26% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱DHODH-IN-15
描述DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.
體外活性DHODH-IN-15 is a hydroxyfuran analogue of A771726, in which the biphenyl skeleton does not carry any substituents. Turning to the derivative DHODH-IN-15, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, DHODH-IN-15 was found to bind in a BQN-like manner, ie, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. On 1D3G and 1UUO, in any case, no interaction of Tyr356 with Leflunomide was found, but when 2BXV was used as a docking target, a large part of this posture was found[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (195.54 mM)
關(guān)鍵字DHODH-IN-15 | DHODHIN15 | DHODH IN 15
相關(guān)產(chǎn)品Disulfiram | Methotrexate | ALDH1A3-IN-3 | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Benzyl alcohol | Isomalt | Isoniazid | Sodium Oxamate | Ivosidenib
相關(guān)庫經(jīng)典已知活性庫 | 抗癌細(xì)胞代謝庫 | 抑制劑庫 | 線粒體靶向庫 | 代謝化合物庫 | 免疫/炎癥分子化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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