Desloratadine NEW
| Price | $46 | $63 | $241 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Desloratadine | CAS No.: 100643-71-8 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Desloratadine |
| Description | Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching and spasmodic contractions of gastrointestinal smooth muscle. Desloratadine is used to provide symptomatic relieve of allergic symptoms. |
| In vitro | Desloratadine inhibits histamine-induced paw edema in mice, with an ED50 of 0.15 mg/kg, and exhibits dose-dependent and sustained mydriasis in guinea pigs in vivo at concentrations of 1 mg/mL, 3 mg/mL, and 10 mg/mL. It also suppresses the increase in vascular permeability in guinea pigs caused by histamine assault on the upper respiratory tract, with an ED50 of 0.9 μg. Furthermore, 5 mg/kg desloratadine counteracts the disruption of the blood-brain barrier in awake mice, thereby inhibiting tremors induced by the tremogenic agent oxotremorine. |
| In vivo | Desloratadine acts as a competitive antagonist to carbachol-induced contractions in isolated rabbit iris sphincter muscles, with a pA2 of 6.67. It binds to the human H1 receptor with a Ki value of 0.87 nM, displacing tritiated mepyramine. In competitive binding studies, Desloratadine was found to be more effective than cetirizine, ebastine, fexofenadine, and loratadine by factors of 52, 57, 194, and 153, respectively. Desloratadine (0.1 μM to 10 μM) also inhibits platelet-activating factor-induced chemotaxis and TNF-α-induced adhesion of eosinophils in patients with allergic rhinitis or asthma. Furthermore, it dose-dependently reduces IL-13 secretion from human basophils activated by IL-3 and PMA across the same concentration range. Pre-treatment with Desloratadine at 10 μM results in an approximately 80% reduction in anti-IgE-induced accumulation of IL-4 messages in cultured basophils. [3H]Desloratadine binds to human histamine H1 receptors expressed in CHO cells with a Kd of 1.1 nM. Concentrations of Desloratadine ranging from 100 nM to 10 μM were found to inhibit both IgE-mediated and non-IgE-mediated production of cytokines IL-4 and IL-13 in human basophils. Additionally, Desloratadine at 300 nM to 100 μM inhibits the release of histamine from human peripheral blood basophils stimulated by both IgE-mediated and non-IgE-mediated pathways. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 31.1 mg/mL (100 mM) DMSO : 40 mg/mL (128.69 mM), Sonication is recommended. |
| Keywords | NSC675447 | Endogenous Metabolite | Desloratadine | Sch 34117 | Histamine Receptor | inhibit | Sch-34117 | Inhibitor | NSC-675447 |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Natural Product Library for HTS | FDA-Approved Drug Library | Anti-Aging Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1g |
VIP1Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2024-11-15 | |
| $0.00/25KG |
VIP5Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2024-10-11 | |
| $0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-05-21 | |
| $0.00/10mg |
VIP1Y
|
ShenZhen H&D Pharmaceutical Technology Co., LTD
|
2024-05-14 | |
| $0.00/1KG |
VIP1Y
|
Hangzhou Hyper Chemicals Limited
|
2024-04-10 | |
| $35.00/1kg |
VIP1Y
|
Sigma Audley
|
2024-03-12 | |
| $100.00/1kg |
Henan Bao Enluo International TradeCo.，LTD
|
2023-08-04 | ||
| $0.00/1KG |
VIP2Y
|
Wuhan Haorong Biotechnology Co.,Ltd
|
2023-07-27 | |
| $0.00/1kg |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-10-10 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY